ReviewMedComm2025
Stroke: Epidemiology, Risk Factors, Signaling Pathways, and Clinical Management.
Review in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diversity and taxonomic differences in the oral microbiota of stroke patients: a systematic review and meta-analysis.Frontiers in microbiology · 2026Pooled it
- Intravenous thrombolysis for acute ischemic stroke in the extended time window of 4.5-24 h: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in neurologyPooled it
- The Role of the Microbiome in Lichen Sclerosus: Pathophysiological Insights and Therapeutic Implications.Dermatology and therapy · 2026Review
- Potentiation of GPR68 alleviates post-ischemia BBB dysfunction and brain edema in mice.Experimental neurology · 2026Article
- Body Mass Index Category and the Association Between Polypharmacy and Functional Recovery in Stroke Patients: A Retrospective Cohort Study.Drugs & aging · 2026Article
- Japanese Anticholinergic Risk Scale and Domain-Specific Functional Outcomes in Older Poststroke Patients.Geriatrics & gerontology international · 2026Article
- Therapeutic Potential of Oxiracetam in Neurocognitive Disorders: A Narrative Review.Brain and behavior · 2026Review
- Metabolically induced intestinal inflammation: the role of ER stress and autophagy in a porcine model of diabetes.Molecular and cellular biochemistry · 2026Article
- Heterogeneity in symptom burden and supportive care needs among older adults with ischemic stroke: a cross-sectional study.BMC geriatrics · 2026Article
- Spatiotemporal dynamics of brain pericytes in ischemic stroke.Journal of neuroinflammation · 2026Review
- Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.Journal of translational medicine · 2026Article
- Review
- How far is too far? Geographic distance and outcomes in acute ischemic stroke in a middle-income country.Frontiers in neurologyArticle
- Association between platelet to white blood cell ratio and post-stroke epilepsy in patients with acute ischemic stroke: a multicenter retrospective cohort study.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke can be classified into ischemic stroke (IS), hemorrhagic stroke (HS), and subarachnoid hemorrhage. The high incidence, disability, and mortality rates, especially from IS, place a huge burden on global health. The pathophysiological processes following IS mainly involve energy deficiency, ion homeostasis imbalance, oxidative stress, neuroinflammation, programmed cell death, blood-brain barrier disruption, and cerebral edema. Transient ischemic attack is an early warning sign of IS, characterized by temporary neurological deficits. HS mainly involves primary damage caused by the mass effect of hematoma and secondary damage caused by the toxic components of hematoma. Although advances in acute-phase reperfusion technology have reduced mortality, the fundamental challenge of a narrow therapeutic window limits patient eligibility and long-term recovery outcomes. This review aims to provide a comprehensive overview of stroke, detailing its epidemiology, risk factors, pathophysiological mechanisms, signaling pathways, and clinical management methods. Here, we focus on the latest research progress in IS and emphasize the hope that regenerative therapies, especially stem cell therapies, offer for stroke patients. This review aims to provide a detailed overview of current research and clinical practice in stroke, propose emerging strategies for treating stroke patients, and provide an outlook on future research directions in this field.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.