Evidence map›Paper›PMID 41427049›Full record

SynthesisFrontiers in endocrinology2025

BMI is associated with sperm quality and sex hormones in men: a meta-analysis.

Fengming Ji, Bing Yan, Chenghao Zhanghuang, Chengchuang Wu, Jinshuan Dai, Shengde Wu

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Fengming JiUrology Surgery Department Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China.
Bing YanUrology Surgery Department of the Children's Hospital of Kunminng Medical University, Kunming Chlidren's Hospital, Key Laboratory of Children's Major Disease Research of Yunnan Province, Kunming, Yunnan, China.
Chenghao ZhanghuangUrology Surgery Department of the Children's Hospital of Kunminng Medical University, Kunming Chlidren's Hospital, Key Laboratory of Children's Major Disease Research of Yunnan Province, Kunming, Yunnan, China.
Chengchuang WuUrology Surgery Department of the Children's Hospital of Kunminng Medical University, Kunming Chlidren's Hospital, Key Laboratory of Children's Major Disease Research of Yunnan Province, Kunming, Yunnan, China.
Jinshuan DaiUrology Surgery Department of the Children's Hospital of Kunminng Medical University, Kunming Chlidren's Hospital, Key Laboratory of Children's Major Disease Research of Yunnan Province, Kunming, Yunnan, China.
Shengde WuUrology Surgery Department Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To systematically evaluate the relationship between body mass index (BMI) and sperm quality parameters as well as sex hormones levels in males. Method: A comprehensive literature search was conducted across Pubmed, Embase and the Cochrane Library for literature, China National Knowledge Infrastructure, and Wanfang database. Studies investigating the association between BMI and semen parameters or sex hormones in adult males (>18 years) were included. Two reviewers independently performed study selection, data extraction, and quality evaluation Meta-analysis was performed using RevMan 5.4 and Stata 18.0. Results: Of the 275 studies identified, 14 met the inclusion criteria. A total of 14 studies involving 8443 patients were included, including 3467 cases of normal BMI, 3444 cases of overweight and 1532 cases were obesity. All 14 studies involved sperm quality analysis, and 4 studies addressed sex hormone analysis. The meta-analysis results indicate that there were statistically significant differences in normal morphology (NM), total motility (TM), sperm concentration (SC), progressive motility (PM), volume and total sperm count (TSC) among the three groups. In the analysis of sex hormones, total testosterone (TT), follicle stimulating hormone (FSH) and luteinizing hormone (LH) showed statistically significant difference among three groups. Conclusion: Elevated BMI is significantly associated with impaired sperm quality and altered sex hormone levels. BMI should be considered a risk factor in male fertility assessments. Further longitudinal studies are needed to explore the reversibility of these effects through lifestyle interventions.

Indexed as

Body Mass IndexGonadal Steroid HormonesObesitySemen AnalysisSpermatozoaAdultHumansMaleSperm CountSperm MotilityGonadal Steroid HormonesBMImenmeta-analysissex hormonessperm quality

Identifiers

PMID41427049
PMCPMC12714629

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.