Evidence map›Paper›PMID 41427064›Full record

ReviewSovremennye tekhnologii v meditsine2025

Protein Misfolding in the Pathogenesis and Diagnosis of Neurodegenerative Diseases (Review).

P P Tregub, N A Kolotyeva, P A Chekulayev, A A Groshkov, S N Illarioshkin, A B Salmina, M A Piradov

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sovremennye tekhnologii v meditsine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

P P TregubMD, DSc, Senior Researcher, Laboratory of Experimental and Translational Neurochemistry, Institute of the Brain; Russian Center for Neurology and Neurosciences, 80 Volokolamskoye shosse, Moscow, 125367, Russia; Professor, Department of Pathological Physiology; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia.
N A KolotyevaMD, DSc, Associate Professor, Head of the Laboratory of Experimental and Translational Neurochemistry, Institute of the Brain; Russian Center for Neurology and Neurosciences, 80 Volokolamskoye shosse, Moscow, 125367, Russia.
P A ChekulayevStudent; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia.
A A GroshkovJunior Researcher, Laboratory of Experimental and Translational Neurochemistry, Institute of the Brain; Russian Center for Neurology and Neurosciences, 80 Volokolamskoye shosse, Moscow, 125367, Russia.
S N IllarioshkinMD, DSc, Professor, Academician of the Russian Academy of Sciences, Deputy Director for Research; Director of the Institute of the Brain; Russian Center for Neurology and Neurosciences, 80 Volokolamskoye shosse, Moscow, 125367, Russia.
A B SalminaMD, DSc, Corresponding Member of the Russian Academy of Sciences, Professor, Head of the Laboratory of Neurobiology and Tissue Engineering; Russian Center for Neurology and Neurosciences, 80 Volokolamskoye shosse, Moscow, 125367, Russia.
M A PiradovMD, DSc, Professor, Academician of the Russian Academy of Sciences, Director; Russian Center for Neurology and Neurosciences, 80 Volokolamskoye shosse, Moscow, 125367, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review systematizes existing data on protein misfolding in the pathogenesis of neurodegenerative diseases (with a focus on α-synuclein, β-amyloid, and tau protein). Modern laboratory and neuroimaging methods used for clinical diagnosis and scientific research of proteinopathies are discussed. The paper describes promising protein amplification techniques that enable the detection of ultra-low concentrations of aberrant protein forms in biological fluids. The challenges and prospects of early diagnosis of neurodegenerative diseases through protein misfolding detection are also shown.

Indexed as

alpha-SynucleinAmyloid beta-PeptidesNeurodegenerative DiseasesProtein FoldingProteostasis Deficienciestau ProteinsHumansalpha-SynucleinAmyloid beta-Peptidestau ProteinsAlzheimer’s diseasebiomarkersmisfoldingneurodegenerative diseasesParkinson’s diseaseprotein amplification

Identifiers

PMID41427064
PMCPMC12715484

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.