Evidence mapPaperPMID 41427178Full record

ArticleACS omega2025

Design and Synthesis of Novel Chalcone Derivatives Targeting Bladder and Liver Cancer: Cytotoxicity Evaluation and Preliminary Mechanistic Studies.

Aline Mol Hermenegildo, Izadora Amaral Nakao, Luana Beatriz Araújo Vaz, Gabrielly Guimarães Coutinho, João Lucas Moraes Toledo, Tamires Cunha Almeida, Tatiane Roquete Amparo, Kamila de Fatima Anunciação, Glenda Nicioli da Silva, Geraldo Célio Brandão and 2 more

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aline Mol HermenegildoSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
Izadora Amaral NakaoSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
Luana Beatriz Araújo VazSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
Gabrielly Guimarães CoutinhoSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
João Lucas Moraes ToledoSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
Tamires Cunha AlmeidaCenter for Development and Innovation, Butantan Institute, Sao Paulo, SP 05509-002, Brazil.
Tatiane Roquete AmparoSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
Kamila de Fatima AnunciaçãoSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
Glenda Nicioli da SilvaSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
Geraldo Célio BrandãoSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
Saulo Fehelberg Pinto BragaSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.
Thiago Belarmino de SouzaSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG 35402-163, Brazil.ORCID https://orcid.org/0000-0003-3627-6407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high incidence and mortality rates of bladder and liver cancers, combined with the challenges of early diagnosis, contribute to significant strain on healthcare systems. Standard chemotherapy treatments, which commonly use drug combinations, often cause intense side effects, reducing patient compliance and limiting therapeutic success. Considering the promising activity of a chalcone derivative of 2-methoxy-4-propylphenol against HepG2 cancer cells (hit compound

Identifiers

PMID41427178
PMCPMC12713470

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.