Evidence map›Paper›PMID 41427375›Full record

ArticlebioRxiv : the preprint server for biology2025

A bifunctional optical reporter for tracking estrogen response dynamics in neurons.

Alexandra L Cara, Eartha Mae Guthman, Aarya Mishra, Alexanne L Hall, Sae Yokoyama, Norma P Sandoval, Ian Gregg, Krisha Aghi, Kiran K Soma, Stephanie M Correa and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Alexandra L CaraDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, USA.ORCID 0000-0002-2140-2573
Eartha Mae GuthmanPrinceton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0002-2190-7520
Aarya MishraDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, USA.
Alexanne L HallDepartment of Psychology, University of British Columbia, Vancouver, BC, Canada.
Sae YokoyamaPrinceton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.
Norma P SandovalDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, USA.
Ian GreggPrinceton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.
Krisha AghiDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, USA.
Kiran K SomaDepartment of Psychology, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-2169-8092
Stephanie M CorreaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, USA.ORCID 0000-0002-6221-689X
Annegret L FalknerPrinceton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0001-9756-7887
J Edward van VeenDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, USA.ORCID 0000-0003-1798-3210

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Mapping experience-dependent change in a circuit for aggressionR01MH126035 · NIMH · PRINCETON UNIVERSITY · PI FALKNER, ANNEGRET LEA · 2021 to 2025
$2.6M
Generating pro-resilient states through individualized circuit read-write therapeuticsDP2MH126375 · NIMH · PRINCETON UNIVERSITY · PI FALKNER, ANNEGRET LEA · 2020 to 2020
$2.4M
Estrogenic modulation of neural circuits that control temperatureR01AG066821 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CORREA, STEPHANIE · 2020 to 2024
$2.1M
Mapping Neural Dynamics in Hormone-sensitive NetworksK99MH135212 · NIMH · PRINCETON UNIVERSITY · PI GUTHMAN, EARTHA MAE · 2024 to 2025
$272k
Experience dependent regulation of subcortical neural circuits for aggressionF32MH126562 · NIMH · PRINCETON UNIVERSITY · PI GUTHMAN, EARTHA MAE · 2022 to 2024
$169k
NCATS NIH HHS UL1 TR001881NIA NIH HHS R01 AG066821NIMH NIH HHS DP2 MH126375NIMH NIH HHS F32 MH126562NIMH NIH HHS K99 MH135212NIMH NIH HHS R01 MH126035
6 · The paper itself

Abstract

Estrogens are inherently dynamic signaling molecules whose fluctuations induce profound shifts in physiology and behavior. However, methods for tracking the dynamics of estrogen action

Indexed as

estrogen receptorestrogen signalingnuclear receptorviral reporter

Identifiers

PMID41427375
PMCPMC12712938

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.