ArticlebioRxiv : the preprint server for biology2025
A neuron type-specific microexon in
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Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
37 authors.
Shah AlamDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-5806-5603
Georgia DermentzakiDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
David Cabrera-GarciaDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Miao LiDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Ruizhi WangDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Melissa CampbellDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Ilaria BalboDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Brittany L PhillipsDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Min LiInstitute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Jessica EstradaDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Marianna ZazhytskaDepartment of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Yow-Tyng YehDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Lia MinDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Elizabeth RafikianMouse Neurobehavioral Core Facility, Columbia University Irving Medical Center, New York, NY 10032, USA.
Elizabeth ValenzuelaDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.
Brian JosephDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Tulsi PatelDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Dmytro UstienenkoDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Helene LovettDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Huijuan FengDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Xiaojian WangDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Susan Brenner-MortonMortimer B. Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York 10032, USA.
Chyuan-Sheng LinDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Clarissa L WaitesDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Hynek WichterleDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Lizhen ChenBarshop Institute for Longevity and Aging Studies, Department of Cell Systems and Anatomy, UTHSCSA, San Antonio, TX 78229, USA.
Mu YangMouse Neurobehavioral Core Facility, Columbia University Irving Medical Center, New York, NY 10032, USA.
Edmund AuDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Marko JovanovicDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.
Stavros LomvardasDepartment of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Paul M JenkinsDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Rui YangInstitute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Sheng-Han KuoDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Yueqing PengDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-3488-0670
Guang YangDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Neil L HarrisonDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Chaolin ZhangDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Funding
UC San Diego FIRST ProgramU54CA272220 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIA ELENA MARTINEZ, Joann Trejo · 2022 to 2026
$21.2MComplexity and evolution of splicing-regulatory networksR35GM145279 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chaolin Zhang · 2022 to 2026
$4.6MUncovering the Roles of Ubiquitination and the ESCRT Pathway in Degradative Sorting of SV Proteins.R01NS080967 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAITES, CLARISSA LEIGH · 2013 to 2023
$3.8MThe roles of anesthetics and neuroimmune interactions in postoperative cognitive dysfunctionR35GM131765 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Guang Yang · 2019 to 2026
$3.4MRNA Regulatory Networks in Neuronal Cell Type Diversity and FunctionR01NS125018 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chaolin Zhang · 2022 to 2026
$3.0MTargeting Cerebellar Endoplasmic Reticulum Calcium Handling in Essential TremorR01NS124854 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHYLLIS L FAUST, Sheng-Han Kuo · 2022 to 2026
$2.9MMapping proximal and distal splicing-regulatory elementsR01HG012359 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chaolin Zhang · 2023 to 2026
$2.4MThe role of CELF2 and its genetic variants in Alzheimer's diseaseR01AG070214 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHEN, LIZHEN · 2021 to 2025
$2.2MTargeting Cerebellar Excitatory Synapses for Tremor ProgressionR01NS118179 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2020 to 2024
$2.2MTranscriptional Control of Motor Neuron MaturationR01NS116141 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WICHTERLE, HYNEK · 2020 to 2024
$1.9MAlcohol and Interneurons in the Prefrontal CortexR01AA030604 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NEIL L. HARRISON · 2023 to 2026
$1.9MEngineering alternative splicing programs to accelerate maturation of stemcell-derived neuronsR01NS141179 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Hynek Wichterle, Chaolin Zhang · 2025 to 2026
$1.3MNCI NIH HHS U54 CA272220NHGRI NIH HHS R01 HG012359NIAAA NIH HHS R01 AA030604NIA NIH HHS R01 AG070214NIGMS NIH HHS R35 GM131765NIGMS NIH HHS R35 GM145279NINDS NIH HHS K99 NS121136NINDS NIH HHS R01 NS080967NINDS NIH HHS R01 NS116141NINDS NIH HHS R01 NS118179NINDS NIH HHS R01 NS124854NINDS NIH HHS R01 NS125018NINDS NIH HHS R01 NS136686NINDS NIH HHS R01 NS141179
Abstract
Recent studies have revealed many alternative exons differentially spliced across diverse neuron types in the mammalian brain, but their links to neuronal physiology remain unclear. Here we characterize a deeply conserved microexon E35a in
Indexed as
Ankyrin-G (AnkG)calcium signalingmicroexonneuronal excitabilityneuron type-specific alternative splicing
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What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.