Evidence map›Paper›PMID 41427424›Full record

ArticleRegenerative biomaterials2025

Biomimetic bone-vessel interface-on-a-chip for simulating periodontal physiological and pathological microenvironment.

Chen Chen, Jianan Hui, Tian Tian, Laidi Jin, Xue Li, Bingcheng Lin, Guowu Ma, Hongju Mao, Huiying Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen ChenSchool of Stomatology, Dalian Medical University, Dalian 116044, China.
Jianan HuiState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Tian TianState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Laidi JinSchool of Stomatology, Dalian Medical University, Dalian 116044, China.
Xue LiSchool of Stomatology, Dalian Medical University, Dalian 116044, China.
Bingcheng LinDepartment of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Guowu MaSchool of Stomatology, Dalian Medical University, Dalian 116044, China.
Hongju MaoState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Huiying LiuSchool of Stomatology, Dalian Medical University, Dalian 116044, China.ORCID https://orcid.org/0000-0002-0385-3557

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is a chronic inflammatory disease affecting periodontal supporting tissues. Untreated, it causes irreversible alveolar bone destruction, ultimately leading to tooth loss. Periodontitis-associated pathogenic bacteria/metabolites and pro-inflammatory factors can initiate or exacerbate systemic disease through the circulation. Endothelial cells, forming the interface between circulation and tissues, play a key role in disease progression. As microfluidic organ chips enable the establishment of tissue-tissue interfaces and simulation of the

Indexed as

bone-vessel interfaceinflammationmicrofluidic technologyorgan-on-a-chip

Identifiers

PMID41427424
PMCPMC12714388

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.