ArticleJournal of virology2026
CircRNA-encoded protein fine-tunes ROS homeostasis and engages conserved JAK-STAT antiviral defenses in
Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Oxidative-Stress-Associated Molecular Signatures in Immune-Mediated Diseases: A Systematic Review Integrating Machine Learning and Systems Biology Approaches.Antioxidants (Basel, Switzerland) · 2026Review
- Convergent hub pathways targeted by IAV, SARS-CoV-2, and RSV in type II alveolar epithelial cells: molecular mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Multicellular organisms rely on multilayered immune systems to defend against pathogen invasion. In IMPORTANCE: Antiviral immunity depends on the balance between host defenses and viral countermeasures. In fruit flies, RNA interference (RNAi) represents the primary barrier to viral infection, but viruses often disable this pathway. We show that the circRNA-encoded protein CRAV provides a backup defense by directly binding the NADPH oxidase Nox to generate moderate reactive oxygen species (ROS). Unlike damaging oxidative stress, these ROS serve as signaling cues that activate p38 and JAK-STAT pathways, which in turn drive antiviral cytokine production. This study uncovers how a circRNA-derived protein engages conserved redox-sensitive immune signaling, illustrating an adaptive strategy that ensures protection when RNAi is compromised. The results provide fundamental insights into the evolutionary diversification of circRNA-encoded proteins and broaden our understanding of how finely tuned ROS signaling contributes to innate antiviral immunity.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.