Evidence map›Paper›PMID 41427728›Full record

ArticlemBio2026

The unique role of

Isabel Martín-Blecua, Jorge Sastre-Domínguez, José Ramón Valverde, Pablo García-Bravo, Ángel Ruiz-Enamorado, Rafael Prados-Rosales, Lahari Das, William R Jacobs, Álvaro San Millán, Jesús Blázquez and 1 more

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Isabel Martín-BlecuaDepartment of Microbial Biotechnology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.ORCID 0000-0002-9240-6176
Jorge Sastre-DomínguezDepartment of Microbial Biotechnology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.ORCID 0000-0001-9585-6765
José Ramón ValverdeScientific Computing Service, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.ORCID 0000-0002-6655-7114
Pablo García-BravoDepartment of Microbial Biotechnology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.
Ángel Ruiz-EnamoradoDepartment of Microbial Biotechnology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.ORCID 0009-0001-1097-6459
Rafael Prados-RosalesDepartment of Preventive Medicine, Public Health, and Microbiology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.ORCID 0000-0001-5964-0166
Lahari DasDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-8951-9532
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0003-3321-3080
Álvaro San MillánDepartment of Microbial Biotechnology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.ORCID 0000-0001-8544-0387
Jesús BlázquezDepartment of Microbial Biotechnology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.ORCID 0000-0003-0495-3848
Sonia GullónDepartment of Microbial Biotechnology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.ORCID 0000-0003-1933-7984

Funding

Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
MOLECULAR GENETIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSISR01AI026170 · NIAID · YESHIVA UNIVERSITY · PI JACOBS, WILLIAM ROBERT · 1989 to 2022
$7.1M
Role of mycobacterial dynamin-like proteins in the biogenesis of membrane vesicles, and host-pathogen interactionsR01AI162821 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI RODRIGUEZ, GLORIA MARCELA, SALGAME, PADMINI · 2021 to 2025
$3.4M
Ministerio de Ciencia e Innovación PID2022-136611OB-I00Ministerio de Ciencia e Innovación PRE2021-099108NIAID NIH HHS R01 AI026170NIAID NIH HHS R01 AI162821NIAID NIH HHS R37 AI026170
6 · The paper itself

Abstract

DNA surveillance mechanisms are crucial for maintaining genome stability and minimizing mutation rates. Mismatch repair (MMR) corrects replication errors that escape DNA-polymerase proofreading. In most organisms, MMR is orchestrated by MutS and MutL proteins. However, certain Archaea and Actinobacteria, including the major human pathogen

Indexed as

Bacterial ProteinsDNA Mismatch RepairDrug Resistance, BacterialEndodeoxyribonucleasesMycobacterium tuberculosisAntitubercular AgentsEvolution, MolecularHumansMutationMutation RateAntitubercular AgentsBacterial ProteinsEndodeoxyribonucleasesantibiotic resistanceDNA repairgenome stabilityhypermutationmutation rateMycobacterium tuberculosisnon-canonical mismatch repairNucS/EndoMS

Identifiers

PMID41427728
PMCPMC12892979

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.