ArticleSleep2026
Region-specific pericyte Ca2+ transient dynamics and capillary hemodynamics during the sleep-wake cycle.
Article in Sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
STUDY
objectivesBrain pericytes play a crucial role in neurovascular coupling, regulating cerebral blood flow in response to changes in local neuronal activity. However, their activities during sleep remain less understood. Our objective is to investigate the dynamic changes in pericyte activity and related hemodynamic changes during the sleep-wake cycle.
methodsUsing an in vivo calcium imaging tool, we recorded cytosolic calcium transient dynamics from brain pericytes across natural sleep-wake cycles in the prefrontal cortex and lateral hypothalamus of mice expressing the calcium sensor GCaMP6f specifically in pericytes. Using an in vivo vascular imaging tool, capillary diameter and red blood cell velocity dynamic changes in prefrontal cortex and lateral hypothalamus were recorded and calculated across natural sleep-wake cycles.
resultsOur results show that prefrontal cortex pericytes exhibit low basal calcium transients during non-rapid eye movement sleep and rapid eye movement sleep, while showing synchronous calcium peaks following transitions from sleep to waking. In contrast, lateral hypothalamus pericytes display diverse calcium transient patterns across the sleep-wake cycle, with 81.3%, 15.6%, and 56.3% presenting calcium peaks during non-rapid eye movement sleep, rapid eye movement sleep, and waking, respectively. Hemodynamic recordings in prefrontal cortex demonstrated greater fluctuations in red blood cell velocity during waking compared to non-rapid eye movement sleep, likely associated with periodic pericyte activations during waking. In lateral hypothalamus, average capillary diameter and red blood cell velocity significantly increased during waking compared to non-rapid eye movement sleep, aligning with the predominantly non-rapid eye movement sleep-ON pattern of pericyte calcium transients and frequent capillary stalling observed during non-rapid eye movement sleep.
conclusionsOur findings identified the region-specific pericyte activity patterns that may contribute to local cerebral blood flow dynamics during natural sleep-wake cycles, emphasizing their importance in maintaining neurovascular function in different vigilant states.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.