ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Influence of autonomic dysfunction on sleep disturbance in drug-naïve patients with Parkinson's disease.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Sleep-Autonomic Interactions in Parkinson's Disease and Multiple System Atrophy: A Comparative Study Using Structural Equation Modeling.Movement disorders clinical practice · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundSleep disturbance (SD) is a common non-motor symptom of Parkinson's disease (PD), and autonomic dysfunction is believed to play a key role in its worsening. However, the independent contribution of each autonomic domain to SD remains unclear. We aimed to investigate the influence of autonomic dysfunction on SD in drug-naïve patients with PD.
methodsWe conducted a cross-sectional study of 89 drug-naïve patients with PD. SD was assessed using the PD Sleep Scale-version-2 (PDSS-2) and Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire. Autonomic symptoms were evaluated using the Scale for Outcomes in PD-Autonomic Dysfunction (SCOPA-AUT). Multiple regression analyses were performed to identify the autonomic domains contributing to the PDSS-2 after adjusting for age, sex, disease duration, motor severity, frontal executive function, depression, and visual illusion.
resultsIn the multivariable analyses, SCOPA-AUT gastrointestinal (β = 0.252, P = 0.018), urinary (β = 0.296, P = 0.004), cardiovascular (β = 0.230, P = 0.024), and thermoregulatory domains (β = 0.240, P = 0.019), along with depression, were independently associated with high PDSS-2 scores. The pupillomotor and sexual domains were not significantly associated with SD. In addition, a decline in blood pressure during the head-up tilt test was associated with high PDSS-2 scores.
conclusionMultiple autonomic domains may contribute to SD in drug-naïve patients with PD. Early identification and management of autonomic dysfunction could improve sleep quality and overall quality of life in this population.
Indexed as
Identifiers
41428012What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.