Evidence map›Paper›PMID 41428013›Full record

ReviewEuropean radiology experimental2025

Personalised medicine through AI-enhanced integration of diagnostic imaging and radiation therapy.

Silvia Bottazzi, Giuditta Chiloiro, Luca Russo, Anna Rame, Alessandra Iacono, Benedetta Gui, Luca Boldrini, Maria Antonietta Gambacorta, Evis Sala

Abstract readReview
In one paragraph

Review in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Silvia BottazziDipartimento di Diagnostica per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. silvia.bottazzi02@gmail.com.ORCID http://orcid.org/0009-0003-7594-898X
Giuditta ChiloiroDipartimento di Diagnostica per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Luca RussoDipartimento di Diagnostica per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Anna RameDipartimento di Scienze radiologiche ed ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy.
Alessandra IaconoDipartimento di Scienze radiologiche ed ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy.
Benedetta GuiDipartimento di Diagnostica per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Luca BoldriniDipartimento di Diagnostica per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Maria Antonietta GambacortaDipartimento di Diagnostica per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Evis SalaDipartimento di Diagnostica per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of diagnostic imaging with radiation therapy (RT) is evolving into a continuous workflow, significantly advancing personalised oncology care. Recent technological innovations, particularly the incorporation of real-time magnetic resonance imaging (MRI) with linear accelerators, have markedly enhanced RT precision, improving target coverage and reducing radiation exposure to surrounding healthy tissues. Furthermore, real-time MRI enables the collection of quantitative imaging data during each treatment fraction, potentially leading to the identification of quantitative imaging biomarkers. These biomarkers can capture dynamic biological changes during RT, offering unprecedented insights into treatment response. The integration of these imaging biomarkers with clinical, genomic, and pathological data into artificial intelligence (AI)-supported clinical decision support systems promises to further refine therapeutic personalisation. In this context, AI plays a central role by automating labour-intensive tasks, extracting quantitative metrics, and integrating multidimensional data into clinically meaningful predictive models. This review outlines a vision for the future of RT, highlighting how the synergy of advanced imaging, AI, and multidomain data through three logical steps: (1) rethinking and reorganising the patient care journey; (2) from imaging "for" to imaging "with" RT; and (3) incorporation into clinical decision support systems. This integration will support the development of personalised, biologically driven treatment strategies. RELEVANCE STATEMENT: The longitudinal integration of diagnostic imaging and RT, facilitated by AI, could significantly enhance clinical workflow efficiency and therapeutic accuracy in oncology. KEY POINTS: Oncological care is transitioning from disease-centred to patient-centred, with tumour boards representing the junction for shared multidisciplinary decisions. Integrating advanced imaging with RT enables quantitative imaging biomarkers extraction that captures tumour changes throughout the course of treatment. Artificial intelligence plays a central role in automating resource-intensive processes and integrating large-scale multidomain data towards personalised medicine.

Indexed as

Artificial IntelligenceDiagnostic ImagingNeoplasmsPrecision MedicineHumansArtificial intelligenceBiomarkers (tumours)Magnetic resonance imagingPrecision medicineRadiotherapy

Identifiers

PMID41428013
PMCPMC12722594

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.