SynthesisEuropean journal of applied physiology2026
Safety and efficacy of exercise training in patients with pulmonary hypertension: a systematic review and meta-analysis.
Synthesis in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Safety of exercise after pulmonary endarterectomy: a systematic review.ERJ open research · 2026Article
- Evolution of Exercise Training in Patients with Pulmonary Hypertension-A Comprehensive Review.Healthcare (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary hypertension (PH) is a progressive disease associated with reduced exercise tolerance and quality of life, despite advances in pharmacologic therapy. Exercise training has recently emerged as a potential non-pharmacological intervention, with growing evidence supporting its clinical benefits. However, optimal training modalities remain uncertain. This study aimed to synthesize current evidence and determine the overall efficacy and safety of exercise training in patients with PH.
methodsThis systematic review and meta-analysis evaluated the effects of structured exercise training programs in adults with Group 1 or 4 PH. PubMed and Cochrane Library were searched to identify randomized controlled trials and non-randomized interventional studies. Key outcomes included exercise capacity [Peak oxygen-uptake (VO2peak), 6-minute walk distance (6MWD)], quality of life, and safety. Data was pooled using a random-effects model, and study quality was assessed with validated risk of bias tools.
resultsThirteen studies, approximately 700 participants, were included. Exercise interventions significantly improved 6MWD (+ 52.5 m, 95%CI: 38.33–66.69, p < 0.001) and VO2peak (+ 1.65 mL/kg/min, 95%CI: 0.67–2.62, p < 0.001). Considerable heterogeneity was observed. Changes in quality-of-life scores were not statistically significant but trended positively. A reduction in pulmonary artery systolic pressure was noted [standardized mean difference (SMD) = − 0.21, 95%CI: −0.33 to − 0.10, p < 0.001], while resting heart rate remained unchanged (SMD = − 0.17, 95%CI: −0.55 to 0.21, p = 0.27). Across all studies, exercise training was consistently well-tolerated, with no serious adverse events directly linked to the interventions.
conclusionExercise training appears to be effective and safe for individuals with PH, improving functional capacity and cardiorespiratory fitness. These findings support its integration into multidisciplinary care.
Indexed as
Identifiers
41428053What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.