Evidence map›Paper›PMID 41428591›Full record

ArticleNeuropsychobiology2026

Plasma Allopregnanolone and Sex Hormone Responses to Stress Induction: Contributors to the Formation of Intrusive Memories.

Khalisa Amir Hamzah, Madeline Jarvis, Natalie P Turner, Ottmar V Lipp, Jonathan M Flintoff, Luke Schmidt, Luke J Ney

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Article in Neuropsychobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Khalisa Amir HamzahSchool of Psychology and Counselling, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia, khalisa.amirhamzah@hdr.qut.edu.au.
Madeline JarvisSchool of Psychology and Counselling, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Natalie P TurnerSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Ottmar V LippSchool of Psychology and Counselling, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Jonathan M FlintoffSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Luke SchmidtSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Luke J NeySchool of Psychology and Counselling, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: Intrusive memories are a central identifying symptom of post-traumatic stress disorder (PTSD), and their development can be modelled in experimental settings with the trauma film paradigm. Neurosteroids and sex hormones, such as allopregnanolone and testosterone, respectively, have recently become potential targets for PTSD pharmacological treatment due to their influence on the stress response.

methodsIn the current study, 49 healthy female participants underwent stress induction and viewed a trauma film. Plasma allopregnanolone, testosterone, and cortisol responses to stress induction and the trauma film were recorded, and stress-induced responses were modelled as predictors of intrusive memory frequency using negative binomial regression models.

resultsCompared to baseline, plasma allopregnanolone and cortisol levels, along with subjective stress, were significantly higher after the stress induction. Plasma cortisol and subjective stress responses to the stress induction task significantly predicted intrusive memories. Allopregnanolone and testosterone did not predict intrusive memories, though allopregnanolone and cortisol stress responses were significantly correlated.

conclusionThese findings expand our current understanding of the biochemical processes of intrusive memory formation under stress. Additionally, changes in allopregnanolone were observed in response to stress, which contributes towards the discussion of neurosteroids and sex hormones as potential pharmacological targets for the treatment of PTSD. </p>.

Indexed as

HydrocortisoneMemoryPregnanoloneStress Disorders, Post-TraumaticStress, PsychologicalTestosteroneAdultFemaleHumansYoung AdultHydrocortisonePregnanoloneTestosteroneAllopregnanoloneHormonesIntrusive memoriesPost-traumatic stress disorderStressTestosteroneTrauma film paradigm

Identifiers

PMID41428591
PMCPMC12826762

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.