ArticlePLoS neglected tropical diseases2025
Insecticide resistance levels, spatial distribution, and kdr mutations in the dengue vector Aedes albopictus of Hong Kong.
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Aedes albopictus (Skuse), a primary dengue vector in Hong Kong, poses significant challenges to public health due to escalating insecticide resistance in Asia. To address this concern, we evaluated resistance profiles of five field-derived Ae. albopictus populations across Hong Kong using WHO insecticide susceptibility bioassays. Metabolic detoxification using synergists test with piperonyl butoxide (PBO) and target-site mutations referred to as knockdown resistance (kdr) in the voltage-gated sodium channel (VGSC) gene were characterized to elucidate resistance mechanisms. The results show that Ae albopictus populations in Hong Kong exhibited high resistance to commonly used pyrethroids (permethrin, deltamethrin) and the organochlorine dichlorodiphenyltrichloroethane (DDT), as well as emerging resistance to the organophosphate malathion. Resistance to three larvicides, temephos, spinosad, and pyriproxyfen, is likely to be developing, whereas Bacillus thuringiensis israelensis (Bti) still retains efficacy. Sequencing revealed the F1534S/L mutation in VGSC Domain III (29.0% mutation frequency), strongly correlated with pyrethroid survivorship. A minor dual mutation (S406T + L424H) in Domain I was recorded but showing limited phenotypic association. Synergist assays demonstrated partial or full restoration of pyrethroid susceptibility with PBO, implicating cytochrome P450-mediated metabolic resistance as a co-factor. These findings confirm that Ae. albopictus in Hong Kong has evolved multifaceted resistance mechanisms, driven by both target-site mutations and metabolic detoxification. This study provides critical evidence to optimize local vector control strategies and contributes resistance profiles to the Asia-Pacific region, aiding regional efforts to mitigate dengue transmission risks.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.