Evidence map›Paper›PMID 41428714›Full record

ArticleJBRA assisted reproduction2026

Piperine protects ovarian follicles and stromal cells against doxorubicin-induced adverse effects in mouse ovaries.

Moisés Bruno Marinho Rocha, Ernando Igo Teixeira de Assis, Venância Antônia Nunes Azevedo, Miguel Fernandes de Lima Neto, Anderson Weiny Barbalho Silva, Alana Nogueira Godinho, Jordânia Marques de Oliveira Freire, Emanoel da Silva Félix, Regislane Pinto Ribeiro, Geovany Amorim Gomes and 1 more

Abstract read
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In one paragraph

Article in JBRA assisted reproduction, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Moisés Bruno Marinho RochaLaboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará, Sobral, CE, Brazil.
Ernando Igo Teixeira de AssisLaboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará, Sobral, CE, Brazil.
Venância Antônia Nunes AzevedoLaboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará, Sobral, CE, Brazil.
Miguel Fernandes de Lima NetoLaboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará, Sobral, CE, Brazil.
Anderson Weiny Barbalho SilvaLaboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará, Sobral, CE, Brazil.
Alana Nogueira GodinhoNucleus of Research in Animal Experimentation (NUPEX), Federal University of Ceará, Sobral, CE, Brazil.
Jordânia Marques de Oliveira FreireNucleus of Research in Animal Experimentation (NUPEX), Federal University of Ceará, Sobral, CE, Brazil.
Emanoel da Silva FélixLaboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará, Sobral, CE, Brazil.
Regislane Pinto RibeiroLaboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará, Sobral, CE, Brazil.
Geovany Amorim GomesCenter of Exact Science and Technology, State University of Acarau Valley, Sobral, CE, Brazil.
José Roberto Viana SilvaLaboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará, Sobral, CE, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigates the effects of Piperine (PIP) on doxorubicin (DOX)-induced changes in mouse ovarian follicles, stromal cells, collagen fibers, and mRNA expression of nuclear factor erythroid 2-related factor (NRF2), superoxide dismutase (SOD), and catalase (CAT).

methodsThe mice were randomly divided into seven groups. In the first three groups, they received saline (1), both DOX and N-acetylcysteine (2), or DOX only (3). In groups 4 and 5, mice were treated with DOX in combination with 0.1 or 10.0mg/kg PIP. In groups 6 and 7, mice received 0.1 or 10.0mg/kg PIP alone. After 10 days, ovaries were collected and used to evaluate follicular morphology and growth, collagen fibers, stromal cells, and mRNA for NRF2, SOD, and CAT.

resultsMice treated with DOX showed reduced percentage of normal follicles, but the combination of DOX with PIP or NAC prevented this effect, maintaining follicle integrity similar to untreated animals. Ovaries of mice treated with PIP alone had similar percentage of normal follicles compared to control group. Additionally, the association of DOX and PIP preserved collagen levels similar to control, while PIP or NAC alone did not influence collagen distribution. Ovaries of mice treated with both DOX and NAC showed a reduction in stromal cells, but those treated with both DOX and PIP maintained the levels of collagens similar to control.

conclusionsThe DOX and PIP preserved the integrity of follicles and collagen fibers in mouse ovaries, which opens a new possibility to protect primordial follicles during chemotherapy.

Indexed as

AlkaloidsAntibiotics, AntineoplasticBenzodioxolesDoxorubicinOvarian FollicleOvaryPiperidinesPolyunsaturated AlkamidesStromal CellsAnimalsCatalaseCollagenFemaleMiceNF-E2-Related Factor 2Superoxide DismutaseAlkaloidsAntibiotics, AntineoplasticBenzodioxolesCatalaseCollagenDoxorubicinNF-E2-Related Factor 2PiperidinespiperinePolyunsaturated AlkamidesSuperoxide Dismutasechemotherapyfertilitygonadal toxicityovarypiperine

Identifiers

PMID41428714
PMCPMC13055168

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.