Evidence map›Paper›PMID 41428884›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Sensing the shape of a surface by tightly surface-bound filaments.

Handuo Shi, Jeffrey Nguyen, Jordan Alexander Huang, Zemer Gitai, Joshua Shaevitz, Benjamin P Bratton, Ajay Gopinathan, Gregory Grason, Kerwyn Casey Huang

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Sensing the shape of a surface by tightly surface-bound filaments.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Handuo ShiDepartment of Bioengineering, Stanford University, Stanford, CA 94305.ORCID 0000-0002-1688-6905
Jeffrey NguyenDepartment of Physics, Princeton University, Princeton, NJ 08540.
Jordan Alexander HuangBowman School, Palo Alto, CA 94306.
Zemer GitaiDepartment of Molecular Biology, Princeton University, Princeton, NJ 08540.
Joshua ShaevitzDepartment of Physics, Princeton University, Princeton, NJ 08540.ORCID 0000-0001-8809-4723
Benjamin P BrattonDepartment of Physics, Princeton University, Princeton, NJ 08540.ORCID 0000-0003-1128-2560
Ajay GopinathanDepartment of Physics, University of California, Merced, CA 95343.ORCID 0000-0002-9369-8780
Gregory GrasonDepartment of Polymer Science and Engineering, University of Massachusetts, Amherst, MA 01003.ORCID 0000-0001-5479-9370
Kerwyn Casey HuangDepartment of Bioengineering, Stanford University, Stanford, CA 94305.ORCID 0000-0002-8043-8138

Funding

A universal pipeline for functional characterization of the human microbiota at a massive scaleRM1GM135102 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BUIE, CULLEN RICHARD, DEUTSCHBAUER, ADAM M · 2020 to 2024
$7.6M
A single-cell approach to developing non-traditional antibioticsDP1AI190418 · NIAID · PRINCETON UNIVERSITY · PI Zemer Gitai · 2024 to 2026
$5.7M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM135102NIAID NIH HHS DP1 AI190418NIGMS NIH HHS RM1 GM135102NSF (NSF) CMMI-154857NSF (NSF) DMR-2028885NSF (NSF) DMR-2349818NSF (NSF) EF-2125383NSF (NSF) HRD-1547848NSF (NSF) HRD-2112675NSF (NSF) PHYS-1607611
6 · The paper itself

Abstract

Understanding the mechanisms that dictate the localization of cytoskeletal filaments is crucial for elucidating cell shape regulation in prokaryotes. The actin homolog MreB plays a pivotal role in maintaining the shape of many rod-shaped bacteria such as

Indexed as

Actin CytoskeletonCytoskeletonEscherichia coliEscherichia coli ProteinsCell MembraneMolecular Dynamics SimulationThermodynamicsEscherichia coli ProteinsMreB protein, E colicurvature enrichmentcytoskeletal filamentsGaussian curvatureintracellular localizationMreB

Identifiers

PMID41428884
PMCPMC12772210

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.