ArticleJournal of obesity & metabolic syndrome2026
Urinary Ferritin: A Non-inflammatory Iron Marker Linked to Insulin Resistance and Metabolic Syndrome Components.
Article in Journal of obesity & metabolic syndrome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Serum ferritin is well known to be associated with chronic inflammation and insulin resistance. This study investigates urinary ferritin as a potential non-invasive biomarker for metabolic alterations and insulin resistance. Methods: This study analyzed ferritin levels in urine samples from two independent cross-sectional cohorts: IRONMET-continuous glucose monitoring (CGM) (a middle-aged cohort, n=78) and Aging Imageomics (an aged cohort, n=47). Associations between urinary ferritin and clinical and biochemical parameters were assessed using correlation analyses. Untargeted plasma metabolomics was performed in the IRONMET-CGM cohort, and differentially abundant metabolites associated with urinary ferritin and ultrasensitive C-reactive protein were identified using linear models for microarray regression analysis. Results: In the IRONMET-CGM cohort, urinary ferritin correlated positively with serum glucose, serum ferritin, and transferrin saturation and negatively with transferrin and total iron-binding capacity. In the Aging Imageomics cohort, urinary ferritin showed positive associations with serum glucose, fasting plasma insulin, low-density lipoprotein cholesterol, serum ferritin, right ankle diastolic blood pressure, and the percentage of mean arterial pressure of the right brachial pulse wave and a negative association with high-density lipoprotein cholesterol. Plasma metabolomics profiling revealed that urinary ferritin was positively associated with succinic acid, adipic acid and cis-4-decenoic acid concentrations, suggesting disruptions in fatty acid metabolism. In contrast, metabolites linked to elevated ultrasensitive C-reactive protein, including 3-hydroxyanthranilic acid and formyl-5-hydroxykynurenamine, were associated with the kynurenine pathway and systemic inflammation. Conclusion: Urinary ferritin is a promising, non-invasive marker of iron metabolism disturbances and metabolic dysregulation. Its associations with glucose metabolism, lipid profiles, and distinct metabolomics signatures suggest potential utility for early detection of metabolic alterations.
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