ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025
[Preoperative serum magnesium as a biomarker for predicting delirium following non-cardiac surgery in elderly patients: a retrospective cohort study].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the association of preoperative serum magnesium (sMg) level with postoperative delirium (POD) in elderly surgical patients and the mediating role of systemic inflammation.
methodsThis retrospective cohort study was conducted among 12 876 patients aged ≥65 years undergoing non-cardiac, non-neurological surgeries at Chinese PLA General Hospital between January, 2014 and December, 2021. Preoperative sMg and C-reactive protein (CRP) levels were measured within 30 days before surgery. POD was identified within 7 days postoperatively using structured chart review based on the Confusion Assessment Method. Multivariate logistic regression and restricted cubic spline (RCS) models were used to evaluate the association between sMg and POD. Mediation analysis with structural equation modeling was used to quantify the indirect effect of CRP after adjusting for the confounding factors.
resultsPOD was identified in 685 (5.3%) of the patients. A significant nonlinear association was observed between preoperative sMg levels and POD risk, and POD incidence was the lowest in patients with sMg levels of 0.90-0.94 mmol/L. Compared with those in the 4th quintile, the patients in the lowest quintile exhibited a markedly increased risk of POD (OR=1.81, 95%
conclusionsPreoperative sMg level is independently associated with an increased POD risk in elderly patients, mediated partly by systemic inflammation. sMg may serve as a modifiable biomarker for early risk stratification and prevention for POD in perioperative care.
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