Evidence map›Paper›PMID 41430102›Full record

ArticleThe journal of headache and pain2025

Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial pain by modulating mitochondrial function and TRPV1/TRPA1 activity.

Zhiting Gong, Morgan Zhang, Naijiang Liu, Kesava Asam, Stefano Martellucci, Bradley Aouizerat, Wendy Campana, Yi Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhiting GongTranslational Research Center, College of Dentistry, New York University, New York, NY, 10010, USA.ORCID http://orcid.org/0000-0002-6398-4268
Morgan ZhangTranslational Research Center, College of Dentistry, New York University, New York, NY, 10010, USA.ORCID http://orcid.org/0000-0001-7670-5304
Naijiang LiuTranslational Research Center, College of Dentistry, New York University, New York, NY, 10010, USA.ORCID http://orcid.org/0009-0005-2477-7636
Kesava AsamTranslational Research Center, College of Dentistry, New York University, New York, NY, 10010, USA.ORCID http://orcid.org/0000-0002-6247-9905
Stefano MartellucciDepartment of Anesthesiology, University of California San Diego, San Diego, CA, 92093, USA.ORCID http://orcid.org/0000-0002-3952-3162
Bradley AouizeratTranslational Research Center, College of Dentistry, New York University, New York, NY, 10010, USA.ORCID http://orcid.org/0000-0002-6047-9397
Wendy CampanaDepartment of Anesthesiology, University of California San Diego, San Diego, CA, 92093, USA.ORCID http://orcid.org/0000-0002-9039-1396
Yi YeTranslational Research Center, College of Dentistry, New York University, New York, NY, 10010, USA. yy22@nyu.edu.ORCID http://orcid.org/0000-0002-1075-5584

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Nancy Chan · 1985 to 2026
$83.1M
NCI NIH HHS P30 CA016087
6 · The paper itself

Abstract

backgroundOrofacial pain, affecting 10-15% of adults, is a prevalent form of chronic pain that remains a major clinical challenge. The Schwann cell involvement in this pathophysiology is not fully understood. Low-density lipoprotein receptor-related protein 1 (LRP1) in Schwann cells has an unclear role in orofacial pain mechanisms.

findingsWe demonstrate that Schwann cell-specific conditional knockout of Lrp1 (scLrp1

conclusionsOur results demonstrate that Schwann cell LRP1 safeguards mitochondrial function and supports neuron-glia metabolic coupling in the trigeminal system. The finding that LRP1 deficiency in Schwann cells drives orofacial pain in the absence of external insults highlights Schwann cells as active drivers, rather than passive amplifiers of chronic pain and identifies LRP1 as a promising target for orofacial pain management.

Indexed as

Facial PainLow Density Lipoprotein Receptor-Related Protein-1MitochondriaNeuronsSchwann CellsTrigeminal GanglionTRPA1 Cation ChannelTRPV Cation ChannelsAnimalsHyperalgesiaMaleMiceMice, Inbred C57BLMice, KnockoutLow Density Lipoprotein Receptor-Related Protein-1Lrp1 protein, mouseTRPA1 Cation ChannelTrpa1 protein, mouseTRPV1 protein, mouseTRPV Cation ChannelsLow-density lipoprotein receptor–related protein 1 (LRP1)Mitochondrial remodelingOrofacial painSchwann cellTRPA1TRPV1

Identifiers

PMID41430102
PMCPMC12750843

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.