Observational studyBMC psychiatry2025
Interrelationships among oxidative stress, niacin response, cognition, and symptoms in chronic schizophrenia: a case-control study.
Observational study in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundA growing body of evidence implicates oxidative stress in the pathophysiology of schizophrenia. This study aimed to analyze the pairwise correlations among the four variables in patients with schizophrenia: oxidative stress (lipid peroxidation), the niacin skin response, cognitive function, and clinical symptoms.
methodsThis cross-sectional observational case-control study included 40 patients with chronic schizophrenia and 40 matched healthy controls. Plasma lipid peroxidation (LPO) levels, the niacin skin flush response, and cognitive function were assessed in all participants. Symptom severity in patients was evaluated using the Positive and Negative Syndrome Scale (PANSS). Regression analyses were conducted to examine the relationships among LPO levels, the niacin skin response, clinical symptoms, and cognitive function.
resultsPlasma LPO levels were significantly higher in the patient group than in the healthy controls, whereas cognitive function and the niacin skin flush response were significantly reduced. Within the patient group, correlation analysis revealed that LPO levels were negatively associated with the total flush area at concentrations 1 and 2 measured at 5 min. Furthermore, significant negative correlations were observed between cognitive function and clinical symptoms across multiple dimensions (all P < 0.05).
conclusionPatients with chronic schizophrenia exhibited elevated oxidative stress (LPO), impaired cognitive function, and attenuated niacin skin flush response. Importantly, oxidative stress showed a negative correlation with the niacin response, while cognitive performance was also negatively correlated with clinical symptom severity. These findings suggest that oxidative stress may be involved in the pathophysiological process of schizophrenia, and that the attenuated niacin skin response could serve as a measurable marker of dysfunction in the peripheral inflammation-oxidative stress axis. CLINICAL TRIAL: Not applicable.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.