ArticleBMC endocrine disorders2025
Metabolic score for visceral fat (METS-VF) is associated with arterial stiffness progression in Type 2 diabetes: a retrospective cohort study of China.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundArterial stiffness is a risk factor for cardiovascular disease (CVD). There is an interaction effect between arterial stiffness and diabetes and may increase the risk of CVD. It is important to find a sensitive biomarker to estimate the risk of arterial stiffness in Type 2 diabetes mellitus (T2DM).
methodsParticipants with type 2 diabetes mellites registered at the Metabolic management center (MMC) of Beijing Luhe Hospital. The association between METS-VF and the progression of arterial stiffness (AS) was evaluated using a logistical regression model, and the odds ratio (OR) and 95% confidence interval (CI) were reported and visualizing the risk of arterial stiffness by drawing restricted cubic splines. The trajectory of the metabolic score for visceral Fat (METS-VF) was fitted with the latent class mixture model (LCMM). Moreover, the Cross-lagged panel model was performed to detect the bidirectional cross-lagged associations between METS-VF and brachial-ankle pulse wave velocity (baPWV).
resultsA total of 701 participants enrolled in the procedure of data analysis. The OR (95%CI) of METS-VF on arterial stiffness progression was 1.54 (1.02, 2.36). We identified three discrete trajectories of METS-VF, the ORs (95%CI) in three trajectories were 1.00 (reference), 1.56 (1.02,2.40), 3.33 (1.65, 6.80), respectively. And there were significant bidirectional cross-lagged associations between METS-VF and baPWV after adjusting for confounding factors, β1 and β2 were 0.025 (95%CI:0.006,0.045, P = 0.011) and 0.211 (95%:0.109,0.312, P < 0.001), respectively.
conclusionsThere was a causal relationship between METS-VF and the progression of arterial stiffness in T2DM. The series of results provided high-quality evidence that controlling METS-VF may affect the progression of arterial stiffness in T2DM. CLINICAL TRIAL NUMBER: Not applicable.
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