ArticleMicrobial cell factories2025
Silver nanoparticles fabricated using phycocyanin from Arthrospira platensis: green synthesis, physicochemical characterization, and biological activities.
Article in Microbial cell factories, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundCyanobacteria and their bioactive components represent a promising potential for the green synthesis of nanoparticles. This work investigates the physicochemical characteristics and biological activities of silver nanoparticles (PC-AgNPs) synthesized using phycocyanin, a photosynthetic pigment extracted from the cyanobacterium Arthrospira platensis Pc-005.
resultsThe phycocyanin-derived AgNPs were characterized using UV-Vis spectroscopy, transmission electron microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), Energy Dispersive X-Ray Spectroscopy (EDX), and Dynamic light scattering (DLS). Physicochemical analysis confirmed the formation of PC-AgNPs, and revealed their nanoscale size, crystalline nature and purity. PC-AgNPs demonstrated a UV-Vis absorption peak at 410 nm. TEM analysis revealed that phycocyanin-derived AgNPs were spherical in shape with an average diameter of 20.0 ± 4.2 nm. XRD and EDX analyses confirmed the crystallinity and purity of PC-AgNPs. FTIR analysis revealed the involvement of phycocyanin functional groups in AgNPs formation. The results demonstrated that PC-AgNPs exhibited strong antimicrobial activity against opportunistic pathogenic bacteria Pseudomonas aeruginosa, Salmonella typhimurium, Staphylococcus aureus, as well as fungi Aspergillus flavus, Penicillium aurantioviolaceum, and Trichoderma viride. The findings indicated that significantly higher concentration of PC-AgNPs was needed to achieve antifungal activity compared to antibacterial activity. The PC-AgNPs also affected the activity of crucial antioxidant enzymes, such as superoxide dismutase and catalase, which play key role in the bacterial defense against oxidative stress induced by AgNPs. Moreover, PC-AgNPs demonstrated significant concentration-dependent anticancer activity against A549 adenocarcinoma cells. They also inhibited key angiogenic factors, including VEGF-A and MMP-2, as well as inflammation-related markers such as TNF-α and COX-2.
conclusionThus, this study provides a comprehensive physicochemical and biological characterization of silver nanoparticles derived from the phycocyanin of A. platensis. The PC-AgNPs exhibit a broad spectrum of biological activities, underscoring their promising potential for innovative applications in biomedical and biotechnological fields.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.