Evidence map›Paper›PMID 41430283›Full record

ArticleDiabetology & metabolic syndrome2025

Correlation of sarcopenic obesity with mild cognitive impairment in middle-aged and older adults: a prospective cohort study based on the nationwide longitudinal survey of CHARLS.

Jielong Wu, Miaona Cai, Zhihai Zhang, Hongfei Ke, Xiaoqing Huang, Jieyi Zhang, Mengyuan Wang, Jingjing Gao, Yingxin Chen, Bing Yan and 3 more

Abstract read
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In one paragraph

Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jielong Wu *Center of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China.
Miaona Cai *Center of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China.
Zhihai ZhangCenter of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China.
Hongfei KeCenter of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China.
Xiaoqing HuangCenter of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China.
Jieyi ZhangCenter of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China.
Mengyuan WangCenter of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China.
Jingjing GaoCenter of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China.
Yingxin ChenFujian University of Traditional Chinese Medicine, Fuzhou, China.
Bing YanCenter of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China.
Nengjiang ZhaoCenter of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China.
Bo LiCenter of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China. libo@xmu.edu.cn.
Xin HuCenter of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen, 361003, China. huxin1987xm@163.com.

Funding

National Natural Science Foundation of China 82205050)
6 · The paper itself

Abstract

backgroundSarcopenic obesity (SO), characterized by concurrent muscle loss and excess adiposity, is an emerging public health challenge, yet prospective evidence linking SO to mild cognitive impairment (MCI) remains limited.

methodsBaseline data were collected from the China Health and Retirement Longitudinal Study (CHARLS) in 2015. The incidences of MCI during follow-ups by 2018 and 2020 were calculated. Participants were divided into healthy, obesity only, sarcopenia only, and SO groups. Aging-associated MCI was defined as a total cognitive score at least one standard deviation below the age-specific norm for participants aged 45 and above, adjusted for age in five-year increments.

resultsIn the 11,674 individuals with an average age of 59.31 ± 9.21 years, SO was detected in 160 (1.37%) individuals. The score of each dimension and total score of cognitive function were lower in the SO group than in the sarcopenia-only group, but with a difference only in the dimension of drawing (P = 0.012). By 2018, 840 MCI cases (12.7%), and by 2020, 1,107 (16.8%) MCI cases were reported. The MCI incidence was higher in the SO group than in the other groups (P < 0.001). The risk of MCI was higher in the SO group than in the other groups (3-year MCI: hazard ratio [HR] 2.11, 95% confidence interval [CI] 1.21, 3.69, P = 0.008; 5-year MCI: HR 1.88, 95% CI 1.09, 3.25, P = 0.024). Older adults and women were more vulnerable to MCI induced by SO.

conclusionSO is correlated with MCI and serves as a risk factor in middle-aged and older adults in China.

Indexed as

Middle-aged and older adultsMild cognitive impairmentObesitySarcopeniaSarcopenic obesity

Identifiers

PMID41430283
PMCPMC12836849

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.