Evidence map›Paper›PMID 41430321›Full record

ArticleDiabetology & metabolic syndrome2025

Statin therapy on dementia in elderly type 2 diabetes patients with delirium.

Mingyang Sun, Xiaoling Wang, Zhongyuan Lu, Yitian Yang, Shuang Lv, Mengrong Miao, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang

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Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Mingyang Sun *Department of Anesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Xiaoling Wang *Department of Anesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Zhongyuan LuDepartment of Anesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Yitian YangDepartment of Anesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Shuang LvDepartment of Anesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Mengrong MiaoDepartment of Anesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Wan-Ming ChenGraduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei, Taiwan.
Szu-Yuan Wu *Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei, Taiwan. szuyuanwu5399@gmail.com.
Jiaqiang Zhang *Department of Anesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China. zhangjiq@zzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetes-related delirium presents a significant challenge in older adults with type 2 diabetes mellitus (T2DM) due to its strong association with cognitive decline and increased dementia risk. Statins, known for their lipid-lowering and neuroprotective properties, may reduce this risk, but their impact in high-risk populations like older T2DM patients with a history of delirium is not fully understood.

methodsThe study included individuals aged 65 and older with T2DM and a history of hospitalization for delirium between January 1, 2008, and December 31, 2019, with follow-up until December 31, 2022. Statin use was defined as at least 28 cumulative defined daily doses (cDDD) per year. Propensity score matching (PSM) was used to balance baseline characteristics between statin users and non-users.

resultsThe study cohort comprised 35,426 matched pairs of statin users and non-users. Statin use was associated with a reduced risk of dementia (adjusted hazard ratio [aHR], 0.80; 95% CI, 0.75-0.85; p < 0.0001) and lower all-cause mortality (aHR, 0.57; 95% CI, 0.54-0.60; p < 0.0001). A dose-response relationship was observed, with higher cDDD of statins correlating with greater reductions in dementia risk.

conclusionsStatin therapy, particularly at higher doses and intensities, is linked to reduced dementia risk and overall mortality in older T2DM patients with a history of delirium. These findings support the potential role of statins in the prevention of dementia in this high-risk population, warranting further investigation through randomized controlled trials.

Indexed as

All-cause mortalityDementia preventionDiabetes-related deliriumStatin therapyType 2 diabetes mellitus

Identifiers

PMID41430321
PMCPMC12723942

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.