ArticleInternational journal of retina and vitreous2025
MicroRNA profiling in serum and humor vitreous of patients affected by vitreoretinal diseases.
Article in International journal of retina and vitreous, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A cross sectional study of optical coherence tomography angiography biomarkers and best corrected visual acuity in epiretinal membrane eyes.International journal of retina and vitreous · 2026Article
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12 authors.
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Abstract
backgroundTo analyze the differential expression of microRNAs (miRNAs) in humor vitreous and serum of patients affected by vitreomacular diseases (VMD) and rhegmatogeneous retinal detachment (RRD). Secondly, to assess their correlation with perfusion parameters during post-operative follow-ups.
methodsPatients diagnosed with vitreomacular interface disease (VMD) and rhegmatogeneous retinal detachment (RRD) scheduled for pars plana vitrectomy (PPV) were included in our prospective interventional study. All patients underwent multimodal imaging including optical coherence tomography angiography (OCTa) and vitreous humor and serum sampling.
resultsA total of 38 participants were enrolled. Among them, 19 (50%) were diagnosed with VMD and 19 (50%) with macula on- RRD. Among the 105 commonly expressed sequences, six miRNAs (hsa-miR-21-5p, hsa-miR-222-3p, hsa-miR-451a, hsa-miR-146a, hsa-miR-144-3p and hsa-miR-320a) were significantly upregulated, despite differences in folds between the vitreous humor and serum levels. In both groups of diseases, hsa-miR-320a showed a significant correlation with the superficial capillary plexus (SCP) macular vessel density in RRD (rho = 0.499) and iVMD (rho = 0.636) while hsa-miR-144-3p exhibited a negative correlation (rho = −0.776) with the SCP variation in the iVMD group.
conclusionThe differential expression of miRNAs in patients affected by VMD and RRD, alongside their correlation with perfusion parameters, supports miRNA application in clinical practice as valuable biomarkers for their potential predictive role.
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