Trial reportBMC anesthesiology2025
Tramadol and postoperative sore throat after tracheal intubation in thyroid surgery - a randomized controlled trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04991493 (Effect of Tramadol on Postoperative Sore Throat in Thyroid Surgery Under General Anesthesia With Endotracheal Intubation), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Tramadol on Postoperative Sore Throat in Thyroid Surgery Under General Anesthesia With Endotracheal Intubation: A Randomized Controlled Trial
Who cites it
1 citing paper in PubMed.
- Prophylactic esketamine for postoperative sore throat: a meta-analysis of randomized evidence.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTramadol is widely employed as part of multimodal perioperative analgesia protocols. Despite its extensive clinical use, no existing literature has specifically investigated the effect of intravenous tramadol on postoperative sore throat (POST) following endotracheal intubation. To address this knowledge gap, we conducted a clinical study evaluating the efficacy of intravenous tramadol in reducing the incidence of POST among patients undergoing tracheal intubation for thyroid surgery.
methodsWe randomized 171 American Society of Anesthesiologists (ASA) physical status I-II female patients scheduled for thyroidectomy into three groups: Control: Standard care without tramadol; Pre-tramadol: Received intravenous tramadol (1 mg/kg) 15 min preoperatively; Post-tramadol: Received intravenous tramadol (1 mg/kg) at the initiation of surgical wound irrigation. The primary outcome was the incidence of POST at 24 h after extubation. Secondary outcomes included the incidence of POST in the post-anesthesia care unit (PACU) and at 4 h after extubation.
resultsThe incidence of POST at rest was 7.1% for Control group, 7.0% for Pre-tramadol group and 1.8% for Post-tramadol group at rest (p = 0.342) at 24 h after extubation; The incidence of POST on movement were 48.2%, 63.2% and 49.1% (p = 0.201) at 24 h after extubation, respectively. Similar results also appeared at PACU and 4 h after extubation.
conclusionsIntravenous tramadol (1 mg/kg) did not significantly reduce the incidence of POST following tracheal intubation in patients undergoing scheduled thyroidectomy.
trial registrationDate of registration: 05/08/2021. ClinicalTrials.gov; Identifer: NCT04991493. URL: https://clinicaltrials.gov/study/NCT04991493 .
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