Evidence map›Paper›PMID 41430587›Full record

ArticleBMC nephrology2025

Increased serum uric acid-to-urinary urate excretion ratio with the kidney function decline in male CKD patients without diabetes: a retrospective cohort study.

Linjing Nie, Rui Peng, Xinhan Ying, Madiya Madeniyet, Dexian Zhang, Sijie Tao, Shiheng Cui, Yujiang Bao, Fuju Zhao, Jing Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Linjing Nie *Department of Nephrology, Huadong Hospital, Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, P.R. China.
Rui Peng *Department of Nephrology, Huadong Hospital, Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, P.R. China.
Xinhan YingDepartment of Nephrology, Huadong Hospital, Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, P.R. China.
Madiya MadeniyetDepartment of Nephrology, Huadong Hospital, Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, P.R. China.
Dexian ZhangDepartment of Nephrology, Huadong Hospital, Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, P.R. China.
Sijie TaoDepartment of Nephrology, Huadong Hospital, Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, P.R. China.
Shiheng CuiDepartment of Nephrology, Huadong Hospital, Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, P.R. China.
Yujiang BaoDepartment of Nephrology, Huadong Hospital, Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, P.R. China.
Fuju ZhaoClinical Laboratory, Huadong Hospital, Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, P.R. China. jasminezhaofuju@126.com.
Jing XiaoDepartment of Nephrology, Huadong Hospital, Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, P.R. China. jingxiao13@fudan.edu.cn.

Funding

the Key Specialized Disease Construction Plan of Huadong Hospital ZDZB2223
6 · The paper itself

Abstract

backgroundThe relationship between uric acid and chronic kidney disease (CKD) progression remains unclear. To study the association between the serum uric acid-to-24-hour-urinary urate excretion ratio (SUER) and kidney events in patients experiencing chronic kidney disease (CKD) progression.

methodsA retrospective cohort study involving 165 CKD patients with estimated glomerular filtration rates (eGFRs) between 15 and 150 mL/min/1.73 m

resultsThe general population aged 56.45 ± 15.76 years, and of which 65 (39.39%) CKD patients are females. The SUER was not the risk of experiencing renal endpoint events in the overall population (OR = 1.05; 95% CI: 0.680, 1.621; P = 0.826), but was an associated factor of renal endpoint events in males without diabetes (OR = 2.196; 95%CI:1.191,4.052; P = 0.012).

conclusionsAn increased SUER may be an indicator for kidney function decline in male CKD patients without diabetes. Further studies should focus on subgroup analyses of CKD patients particularly in male CKD patients without diabetes to evaluate whether uric acid-lowering measures are warranted. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Renal Insufficiency, ChronicUric AcidAdultAgedCohort StudiesDisease ProgressionFemaleGlomerular Filtration RateHumansMaleMiddle AgedRetrospective StudiesUric AcidChronic kidney diseaseRenal functionSerum uric acidUrinary uric acid excretion

Identifiers

PMID41430587
PMCPMC12837049

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.