Evidence map›Paper›PMID 41430688›Full record

ArticleACS infectious diseases2026

Activities of the Novel Bacterial Topoisomerase Inhibitor OSUAB-0284 against the Biothreat Pathogen

Chelsea A Mann, Stephanie A Halasohoris, Annette M Gray, Jennifer Chua, Jade L Spencer, Bobby J Curry, Ashley L Babyak, Christopher P Klimko, Christopher K Cote, Jason S West and 3 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Antimicrobial agents and chemotherapy · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chelsea A MannDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0009-0003-7378-4416
Stephanie A HalasohorisBacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Fort Detrick, Maryland 21702, United States.
Annette M GrayBacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Fort Detrick, Maryland 21702, United States.
Jennifer ChuaBacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Fort Detrick, Maryland 21702, United States.
Jade L SpencerBacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Fort Detrick, Maryland 21702, United States.
Bobby J CurryBacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Fort Detrick, Maryland 21702, United States.
Ashley L BabyakBacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Fort Detrick, Maryland 21702, United States.
Christopher P KlimkoBacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Fort Detrick, Maryland 21702, United States.
Christopher K CoteBacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Fort Detrick, Maryland 21702, United States.
Jason S WestDivision of Medicinal Chemistry and Pharmacognosy, The Ohio State University College of Pharmacy, Columbus, Ohio 43210, United States.
Mark J Mitton-FryDivision of Medicinal Chemistry and Pharmacognosy, The Ohio State University College of Pharmacy, Columbus, Ohio 43210, United States.ORCID 0000-0002-6715-8836
J Matthew MeinigBacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Fort Detrick, Maryland 21702, United States.ORCID 0000-0003-2019-2890
Neil OsheroffDepartments of Biochemistry and Medicine (Hematology/Oncology), Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-2550-4884

Funding

Mechanistic Studies of Gyrase/Topoisomerase IV-Targeted AntibacterialsR01AI170546 · NIAID · VANDERBILT UNIVERSITY · PI NEIL OSHEROFF · 2023 to 2026
$2.7M
Mechanistic Studies of Type II Topoisomerases and Topoisomerase-Targeted AgentsR01GM126363 · NIGMS · VANDERBILT UNIVERSITY · PI OSHEROFF, NEIL · 2018 to 2025
$2.6M
Overcoming Resistance to Novel Bacterial Topoisomerase InhibitorsR01AI173072 · NIAID · OHIO STATE UNIVERSITY · PI Mark J. Mitton-Fry · 2023 to 2026
$2.4M
NIAID NIH HHS R01 AI170546NIAID NIH HHS R01 AI173072NIGMS NIH HHS R01 GM126363
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsBacillus anthracisDNA Topoisomerases, Type IITopoisomerase II InhibitorsTopoisomerase InhibitorsAnimalsAnthraxCiprofloxacinDNA GyraseMicrobial Sensitivity TestsRabbitsAnti-Bacterial AgentsCiprofloxacinDNA GyraseDNA Topoisomerases, Type IITopoisomerase II InhibitorsTopoisomerase InhibitorsanthraxBacillus anthracisgepotidacingyraseOSUAB-0284topoisomerase IV

Identifiers

PMID41430688
PMCPMC12797228

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.