Evidence map›Paper›PMID 41430726›Full record

ArticleEuropean journal of medical research2025

Higher basal ganglia perivascular space burden is associated with reduced deep medullary vein visibility via free water accumulation in sporadic cerebral small vessel disease.

Jie Yu, Xinjun Lei, Zhihua Xu, Haiyuan Lan, Zehui Wu

Abstract read
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In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jie YuDepartment of Radiology, Lishui Hospital of Traditional Chinese Medicine Affiliated Zhejiang Chinese Medical University, Lishui, China.
Xinjun LeiDepartment of Radiology, Lishui Hospital of Traditional Chinese Medicine Affiliated Zhejiang Chinese Medical University, Lishui, China.
Zhihua XuDepartment of Radiology, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Haiyuan LanDepartment of Radiology, Lishui Hospital of Traditional Chinese Medicine Affiliated Zhejiang Chinese Medical University, Lishui, China.
Zehui WuDepartment of Radiology, Lishui Hospital of Traditional Chinese Medicine Affiliated Zhejiang Chinese Medical University, Lishui, China. 1306601985@qq.com.

Funding

Medical and Health Science and Technology Program of Zhejiang Provincial Health Commission of China 2022KY707 and 2024KY866Zhejiang Province Traditional Chinese Medicine Science and Technology Project 2025ZL615
6 · The paper itself

Abstract

backgroundTo investigate the differential associations of basal ganglia perivascular spaces (BGPVS) and centrum semiovale perivascular spaces (CSOPVS) with deep medullary vein (DMV) disruption in cerebral small vessel disease (CSVD), and to explore the potential mediating role of white matter free water (FW) accumulation.

methodsA total of 125 CSVD patients underwent multimodal MRI, including susceptibility-weighted imaging (SWI) for DMV scoring, T2-weighted imaging for PVS grading, and diffusion tensor imaging for FW quantification. DMV visibility was scored (0-18), and PVS were graded (0-4) in BGPVS and CSOPVS regions.

resultsBGPVS score was independently associated with DMV scores (β = 1.566, 95% CI 0.474-2.658, P < 0.05) controlling with age and vascular risk factors, while CSOPVS showed no significant association (P > 0.05). Mediation analysis revealed that FW accumulation partially mediated the BGPVS-DMV relationship (indirect effect = 0.088, 95% bootstrapped CI [0.002, 0.216]), accounting for 34.6% of the total effect.

conclusionsEnlarged BGPVS, but not CSOPVS, is associated with DMV disruption in CSVD, potentially through disrupted perivascular fluid transport and interstitial fluid accumulation.

Indexed as

Basal GangliaCerebral Small Vessel DiseasesCerebral VeinsGlymphatic SystemAgedDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedWaterWhite MatterWaterCerebral small vessel diseaseDeep medullary veinsExtracellular fluidGlymphatic dysfunctionPerivascular spaces

Identifiers

PMID41430726
PMCPMC12723884

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.