Evidence map›Paper›PMID 41431928›Full record

ArticleArchiv der Pharmazie2025

Sequential Optimization Approach Toward an Azapeptide-Based SARS-CoV-2 Main Protease Inhibitor.

Rabea Voget, Victoria Steiger, Julian Breidenbach, Katharina Sylvester, Christin Müller-Ruttloff, Chun-Chiao Yang, John Ziebuhr, Norbert Sträter, Christa E Müller, Michael Gütschow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archiv der Pharmazie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rabea VogetPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany.ORCID https://orcid.org/0009-0003-9249-8773
Victoria SteigerPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany.ORCID https://orcid.org/0009-0005-7665-4523
Julian BreidenbachPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany.
Katharina SylvesterPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany.
Christin Müller-RuttloffInstitute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany.
Chun-Chiao YangInstitute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Leipzig, Germany.
John ZiebuhrInstitute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany.
Norbert SträterInstitute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Leipzig, Germany.
Christa E MüllerPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany.
Michael GütschowPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany.ORCID https://orcid.org/0000-0002-9376-7897

Funding

Deutsche Forschungsgemeinschaft GRK2873 (494832089)the Volkswagen Foundation 9A850the Volkswagen Foundation 9A894
6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative agent of the coronavirus disease 2019 (COVID-19), is still circulating and posing a health threat to the global population. Its main protease (M

Indexed as

Antiviral AgentsAza CompoundsCoronavirus 3C ProteasesCOVID-19 Drug TreatmentPeptidesProtease InhibitorsSARS-CoV-2AnimalsCrystallography, X-RayHumansMolecular StructurePeptidomimeticsStructure-Activity RelationshipVero Cells3C-like proteinase, SARS-CoV-2Antiviral AgentsAza CompoundsCoronavirus 3C ProteasesPeptidesPeptidomimeticsProtease Inhibitorsazapeptideschloroacetohydrazidespeptidomimeticsprotease inhibitorsSARS‐CoV‐2 main protease

Identifiers

PMID41431928
PMCPMC12723578

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.