ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
GPCRs in CAR-T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- GPCRs in CAR-T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- GPCR signaling systems facilitate precision interventions for multi-oncology therapy.Frontiers in systems biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Chimeric Antigen Receptor T cell (CAR-T) therapy has shown significant efficacy in treating hematologic malignancies. However, its application in solid tumors is still challenged by a scarcity of specific targets and the immunosuppressive tumor microenvironment. G protein-coupled receptors (GPCRs), due to their wide distribution and diverse signaling cascades in tumorigenesis, have emerged as promising targets for CAR-T therapy. This review systematically integrates recent advances of GPCR CAR-T therapy for cancer immunotherapy, with a particular emphasis on current targeting strategies and optimization approaches. This includes the identification of GPCRs as novel tumor-associated antigens to expand CAR-T therapeutic applications, co-expressi on of chemokine receptors to enhance tumor infiltration, and utilization ofGPCR signaling pathways to improve CAR-T cell persistence and cytotoxic efficacy. Potential future research directions include application of AI(Artificial Intelligence) to expedite the development of GPCR antibodies, creation of precision therapies targeting GPCR complexes, modulation of GPCR dimerization networks to maintain homeostasis of membrane antigen expression, employment of nanobody platform to enhance targeting specificity, and design of GPCR allosteric modulators as molecular switches for CAR-T cells. Additionally, this review also examines the application of specific antibodies and other immunotherapeutic approaches of GPCRs in oncology. Overall, this review aims to provide novel scientific and therapeutic perspectives for CAR-T cell therapy in treating mutiple types of human cancers.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.