Evidence map›Paper›PMID 41432158›Full record

ArticleMicrobiology spectrum2026

Dronedarone synergizes with colistin against planktonic and biofilm forms of multidrug-resistant Gram-negative pathogens.

Mohamed F Mohamed, Somaia M Abdelmegeed, Abdallah S Abdelsattar, Ahmed A Abouelkhair, Nader S Abutaleb, Mohamed N Seleem

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed F MohamedDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0000-0003-1967-119X
Somaia M AbdelmegeedDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.
Abdallah S AbdelsattarDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0000-0002-2902-3551
Ahmed A AbouelkhairDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0000-0001-9937-742X
Nader S AbutalebDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.
Mohamed N SeleemDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0000-0003-0939-0458

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections caused by multidrug-resistant Gram-negative pathogens (MDR-GNP) are associated with high mortality, prolonged hospital stays, and increased healthcare costs. The treatment of these infections is complicated by the scarcity of new antibiotics and rising resistance to existing drugs. Colistin is often considered a last-resort therapy for MDR-GNP, but its clinical use is limited by significant nephrotoxicity and neurotoxicity. These challenges highlight the need for alternative strategies to enhance the effectiveness of current antibiotics. One promising approach is the use of combination therapy, which can potentiate antimicrobial activity while mitigating toxicity. We screened ~3,400 FDA-approved compounds and identified dronedarone, an antiarrhythmic with a well-established safety profile, as a potent enhancer of colistin activity against several MDR-GNP, including

Indexed as

Anti-Bacterial AgentsBiofilmsColistinDronedaroneDrug Resistance, Multiple, BacterialGram-Negative BacteriaAcinetobacter baumanniiAnimalsCaenorhabditis elegansDrug SynergismEscherichia coliGram-Negative Bacterial InfectionsHumansMicrobial Sensitivity TestsPseudomonas aeruginosaAnti-Bacterial AgentsColistinDronedaronecolistindronedarone,Gram negative

Identifiers

PMID41432158
PMCPMC12889026

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.