Evidence map›Paper›PMID 41432885›Full record

ReviewCardiovascular intervention and therapeutics2026

Absolute coronary blood flow measurement and the principle of microvascular resistance reserve.

Nico H J Pijls, Danielle C J Keulards, Tsunekazu Kakuta, Tetsuya Amano, Hirohiko Ando, Nobuhiro Tanaka, Thabo Mahendiran, Toya Takumi, Hitoshi Matsuo, Thomas R Keeble and 7 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cardiovascular intervention and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nico H J PijlsDepartment of Cardiology, Catharina Hospital, Eindhoven, the Netherlands. nico.pijls@xs4all.nl.
Danielle C J KeulardsDepartment of Cardiology, Catharina Hospital, Eindhoven, the Netherlands.
Tsunekazu KakutaDepartment of Cardiology, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan.
Tetsuya AmanoDepartment of Cardiology, Aichi Medical University, Nagakute, Japan.
Hirohiko AndoDepartment of Cardiology, Aichi Medical University, Nagakute, Japan.
Nobuhiro TanakaDepartment of Cardiology, Hachioji Medical Center, Tokyo University, Hachioji, Japan.
Thabo MahendiranCardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium.
Toya TakumiDivision of Clinical Pharmacology, Showa University School of Medicine, Tokyo, Japan.
Hitoshi MatsuoDepartment of cardiovascular medicine, Gifu Heart University, Gifu, Japan.
Thomas R KeebleEssex Cardiothoracic Centre, Essex, Basildon, UK.
Peter DammanDepartment of Cardiology, Radboud University Hospital, Nijmegen, The Netherlands.
William F FearonDivision of Cardiovascular Medicine, The Stanford Cardiovascular Institute, VA Palo Alto Health Care System, Stanford University School of Medicine, CA, CA, Stanford, Palo Alto, USA.
Takuya MizukamiCardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium.
Pim A L ToninoDepartment of Cardiology, Catharina Hospital, Eindhoven, the Netherlands.
Fernando AlfonsoDepartment of Cardiology, Hospital Universitario de La Princessa, Universidad Autonoma de Madrid, Madrid, Spain.
Bernard De BruyneCardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium.
Takashi AkasakaDepartment of Cardiovascular Medicine, Nishinomiya Watanabe Cardiovascular and Cerebral Center, Watanabe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Measurement of absolute coronary blood flow and myocardial resistance by continuous intracoronary thermodilution was recently introduced and facilitates assessment of the coronary microcirculation. In addition, Microvascular Resistance Reserve (MRR) is a new index that further permits the characterization of coronary microcirculatory function. It can be calculated from resting and hyperemic absolute coronary flow and resistance, measured during continuous thermodilution. By being independent of both epicardial disease and myocardial mass, MRR is highly specific for the microvascular compartment. Measurement of absolute flow, resistance, and MRR by continuous thermodilution has been shown to be accurate and reproducible, with minimal operator interference. In conjunction with the measurement of absolute flow and resistance, MRR could become the index of reference for the diagnosis of coronary microvascular disease and the evaluation of new therapies. In this paper, the basis and practicalities of these measurements are shortly reviewed and its characteristics, its advantages over existing indices, its limitations, and future perspectives are discussed. Word count abstract: 158. Word count text: 7954 (including references and legends).

Indexed as

Coronary CirculationCoronary VesselsMicrocirculationVascular ResistanceBlood Flow VelocityCoronary Artery DiseaseHumansThermodilutionAbsolute Coronary Blood FlowAngina with Non-Obstructive Coronary arteries (ANOCA)Continuous coronary thermodilutionCoronary Flow Reserve (CFR)Coronary microcirculationFractional Flow Reserve (FFR)Microvascular Resistance Reserve (MRR)

Identifiers

PMID41432885

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.