ArticlePflugers Archiv : European journal of physiology2025
Modulation of cardiac contractility and redox balance via cannabinoid type II receptor activation in healthy rats.
Suzana Luisa Alves Fernandes, Yan Costa Gonçalves, Francisco Tadeu Rantin, Ana Lúcia Kalinin, José Wilson Magalhães Bassani, Rosana Almada Bassani, Guilherme Borges Pereira, Diana Amaral Monteiro
Abstract read
In one paragraphArticle in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Suzana Luisa Alves FernandesDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil.
Yan Costa GonçalvesDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil.
Francisco Tadeu RantinDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil.
Ana Lúcia KalininDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil.
José Wilson Magalhães BassaniDepartment of Biomedical Engineering, School of Electrical and Computing Engineering, University of Campinas (Unicamp), Campinas, São Paulo, 13083-881, Brazil.
Rosana Almada BassaniDepartment of Biomedical Engineering, School of Electrical and Computing Engineering, University of Campinas (Unicamp), Campinas, São Paulo, 13083-881, Brazil.
Guilherme Borges PereiraDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil.
Diana Amaral MonteiroDepartment of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565- 905, Brazil. dianamonteiro@ufscar.br.ORCID 0000-0002-1178-6673 Funding
Conselho Nacional das Fundações Estaduais de Amparo à Pesquisa CNPq, grant no. 130995/2022-3Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq, grant no. 301809/2022-4Ministério da Saúde FINEP grant no. 01-13-0214-00
6 · The paper itselfAbstract
The activation of cannabinoid receptor type II (CB2r) has been demonstrated to provide cardioprotective benefits against heart diseases. Nevertheless, the physiological effects of CB2r activation in healthy myocardial tissue remain poorly understood. Given the current gap in knowledge, particularly relevant in light of the growing therapeutic use of cannabinoids, this study aimed to investigate the effects of a single intraperitoneal injection of the selective synthetic CB2r agonist HU-308 on ventricular contractility, the expression of Ca
Indexed as
Myocardial ContractionReceptor, Cannabinoid, CB2AnimalsCalcium-Binding ProteinsCannabinoid Receptor AgonistsCyclic AMPGlutathioneMaleMyocardiumOxidation-ReductionOxidative StressRatsRats, WistarSarcoplasmic Reticulum Calcium-Transporting ATPasesCalcium-Binding ProteinsCannabinoid Receptor AgonistsCyclic AMPGlutathioneReceptor, Cannabinoid, CB2Sarcoplasmic Reticulum Calcium-Transporting ATPasesAntioxidant defense systemCa2+-handling protein expressionCannabinoid agonistCardiac functionMammalsOxidative stress
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