Article in Science signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Adam M BoultonInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic Foundation, Cleveland, OH 44106, USA.ORCID 0000-0002-0102-9572
Megan E GrundInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic Foundation, Cleveland, OH 44106, USA.ORCID 0000-0003-4103-3151
Yuxin WangInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic Foundation, Cleveland, OH 44106, USA.
Erica M OrsiniIntegrated Hospital Care Institute, Department of Pulmonary and Critical Care, Cleveland Clinic Foundation, Cleveland, OH 44106, USA.ORCID 0000-0003-2805-4783
Yan LiuInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic Foundation, Cleveland, OH 44106, USA.ORCID 0000-0002-3961-9172
Mitchell A OlmanInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic Foundation, Cleveland, OH 44106, USA.ORCID 0000-0003-3262-3598
Rachel G ScheragaInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic Foundation, Cleveland, OH 44106, USA.ORCID 0000-0001-5113-543X
Funding
TRPV4-PI3K Axis Mediates Pulmonary and Cardiac FibrosisR01HL133721 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI OLMAN, MITCHELL ALAN, PRASAD, SATHYAMANGLA V · 2017 to 2020
$2.2M
TRPV4 Regulates Mechanosensitive Macrophage Functions in Lung InjuryR01HL155064 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI SCHERAGA, RACHEL GREENBERG · 2021 to 2025
$2.1M
Supporting Multidisciplinary Achievement in Respiratory Research Training (SMARRT)T32HL155005 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Raed A. Dweik · 2021 to 2026
$1.9M
The vital role of T403 phosphorylation of STAT2 in post-viral bacterial pneumoniaR01HL166544 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI YUXIN WANG · 2024 to 2026
$1.7M
Immune Function in Sepsis: Role of SirtuinR35GM149240 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI Vidula Vachharajani · 2023 to 2026
$1.6M
Profibrotic Mechanisms of the TRPV4-PI3K-gamma Protein ComplexR01HL158746 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI OLMAN, MITCHELL ALAN · 2021 to 2024
$1.6M
Transient Receptor Potential Vanilloid 4 (TRPV4) mediates the host defense and lung injury response to bacterial pneumoniaK08HL133380 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI SCHERAGA, RACHEL GREENBERG · 2016 to 2020
$809k
The vital role of T404 phosphorylation of STAT2 in post-viral bacterial pneumoniaR56HL160639 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI WANG, YUXIN · 2022 to 2022
The nuclear factor κB (NF-κB) signaling pathway plays a critical role in activating macrophages in the pathogenesis of many inflammatory diseases. Tissue mechanical properties are important in modulating key cellular proinflammatory responses. Here, we investigated how the mechanosensitive membrane cation channel TRPV4 (transient receptor potential vanilloid 4) limits macrophage proinflammatory responses in bacterial pneumonia. We found that TRPV4 suppressed proinflammatory gene expression in alveolar macrophages in response to
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.