Evidence map›Paper›PMID 41436122›Full record

Trial reportJournal of oral & facial pain and headache2025

Maria Gabriela Rodriguez, Mathew Warchol, Selenia Rubio, Patricia Cabrera, Rory Reever, Sherif Hosney, Cesar A Migliorati, Frank C Gibson Iii, Richard Ohrbach, Roger B Fillingim and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of oral & facial pain and headache, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05916235 (Photobiomodulation for Management of Temporomandibular Disorder Pain), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05916235 narecruitingnot on this map

Photobiomodulation for Management of Temporomandibular Disorder Pain

TypeinterventionalSponsorUniversity of FloridaRan2024 to 2028Enrolled130ConditionsPain Related to TMDArmsTHOR® laser system
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria Gabriela RodriguezDivision of Prosthodontics, Restorative Dental Sciences Department, University of Florida College of Dentistry, Gainesville, FL 32610, USA.
Mathew WarcholDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.
Selenia RubioCommunity Department of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.
Patricia CabreraDivision of Prosthodontics, Restorative Dental Sciences Department, University of Florida College of Dentistry, Gainesville, FL 32610, USA.
Rory ReeverCommunity Department of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.
Sherif HosneyDivision of Prosthodontics, Restorative Dental Sciences Department, University of Florida College of Dentistry, Gainesville, FL 32610, USA.
Cesar A MiglioratiDepartment of Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, FL 32610, USA.
Frank C Gibson IiiDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.
Richard OhrbachDepartment of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, Buffalo, NY 14214, USA.
Roger B FillingimCommunity Department of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.
Shannon WalletDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.
Margarete C Ribeiro DasilvaDivision of Prosthodontics, Restorative Dental Sciences Department, University of Florida College of Dentistry, Gainesville, FL 32610, USA.

Funding

Photobiomodulation for the management of Temporomandibular disorder painUH3DE030433 · NIDCR · UNIVERSITY OF FLORIDA · PI Roger B Fillingim, Margarete C Ribeiro-Dasilva · 2023 to 2026
$3.1M
Photobiomodulation for the management of Temporomandibular disorder painUG3DE030433 · NIDCR · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B, RIBEIRO-DASILVA, MARGARETE C · 2022 to 2022
$559k
NIDCR NIH HHS UG3 DE030433NIDCR NIH HHS UH3 DE030433
6 · The paper itself

Abstract

Temporomandibular disorders (TMD) are a prevalent source of chronic pain and disability, yet current therapies often provide limited relief with notable side effects. Photobiomodulation (PBM) has emerged as a promising non-pharmacologic approach to modulate inflammation and pain. This study investigated the effects of a dual-wavelength PBM protocol (laser + light-emitting diode (LED)) on the lipopolysaccharide (LPS)-stimulated monocyte response from individuals with painful TMD. Monocytes were isolated from 16 individuals with TMD enrolled in a randomized, placebo-controlled clinical trial (NCT05916235). Cells were plated into 96-well plates and divided into Control, LPS, and LPS + PBM treatment groups. Monocytes received four alternating-day treatments with two PBM probes: a laser probe (810/660 nm, 180 J/cm

Indexed as

Low-Level Light TherapyMonocytesTemporomandibular Joint DisordersAdultCells, CulturedCell SurvivalCytokinesFemaleHumansLipopolysaccharidesMaleMiddle AgedYoung AdultCytokinesLipopolysaccharidesCytokinesInflammationMonocytesPhotobiomodulationTemporomandibular disorder

Identifiers

PMID41436122
PMCPMC12727183

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.