Evidence map›Paper›PMID 41436533›Full record

ArticleScientific reports2025

The ADMA-NO-NOX2 axis and its association with leptomeningeal collateral impairment in acute ischemic stroke.

Manuela De Michele, Angela Risitano, Marta Iacobucci, Paolo Amisano, Irene Berto, R Carnevale, V Cammisotto, Angela Pascariello, Matteo Beccia, Antonio Ciacciarelli and 3 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Manuela De MicheleEmergency Department, Stroke Unit, Umberto I Hospital, Sapienza University, Viale del Policlinico, 155, 00161, Rome, Italy. m.demichele@policlinicoumberto1.it.
Angela RisitanoDepartment of Human Neurosciences, Sapienza University, Rome, Italy.
Marta IacobucciDepartment of Human Neurosciences, Neuroradiology Unit, Umberto I Hospital, Sapienza University, Rome, Italy.
Paolo AmisanoDepartment of Human Neurosciences, Sapienza University, Rome, Italy.
Irene BertoEmergency Department, Stroke Unit, Umberto I Hospital, Sapienza University, Viale del Policlinico, 155, 00161, Rome, Italy.
R CarnevaleDepartment of Clinical Internal Anesthesiologic and Cardiovascular Sciences, Sapienza University, Rome, Italy.
V CammisottoDepartment of Medical and Surgical Sciences and Biotechnologies, Sapienza University, Rome, Italy.
Angela PascarielloDepartment of Human Neurosciences, Sapienza University, Rome, Italy.
Matteo BecciaDepartment of Human Neurosciences, Sapienza University, Rome, Italy.
Antonio CiacciarelliEmergency Department, Stroke Unit, Umberto I Hospital, Sapienza University, Viale del Policlinico, 155, 00161, Rome, Italy.
Ettore NicoliniDepartment of Human Neurosciences, Sapienza University, Rome, Italy.
Danilo ToniDepartment of Human Neurosciences, Sapienza University, Rome, Italy.
Svetlana LorenzanoDepartment of Human Neurosciences, Sapienza University, Rome, Italy.

Funding

Sapienza, University of Rome AR120172B783068D
6 · The paper itself

Abstract

Leptomeningeal collateral (LMC) circulation helps preserve brain tissue during acute ischemic stroke (AIS), with poor collateral status predicting worse outcomes. This study assessed the association between asymmetric dimethylarginine (ADMA), LMCs, infarct volume, and oxidative stress in 101 AIS patients with large vessel occlusion within 6 h or wake-up stroke. LMC status was graded using the Menon score (poor, intermediate, or good) on CT angiography, and recanalization was assessed by the modified Thrombolysis in Cerebral Infarction score. Serum ADMA, NADPH oxidase 2 (NOX2), and nitric oxide (NO) levels were measured at admission (< 6 h, T0), 24 h (T1), and 48 h (T2). Among patients, 43.1% had good, 35.3% intermediate, 21.6% poor LMC status. Higher admission ADMA levels were significantly associated with poor LMC at T0 (p = 0.028) and more severe neurological deficits at T1 and T2 (p = 0.005, p = 0.008). ADMA levels increased over time (p = 0.046), and correlated with NOX2 at T1 (p < 0.001). Rising NOX2 was associated with increased neutrophils (p = 0.013) and decreased lymphocytes (p = 0.006). ADMA may impair endothelial function by reducing NO availability and enhancing NOX2-driven oxidative stress. These findings support a role for the ADMA-NO-NOX2 axis in limiting collateral circulation. Targeting this axis may represent a therapeutic strategy to improve outcomes in AIS.

Indexed as

ArginineBrain IschemiaCollateral CirculationIschemic StrokeMeningesNADPH Oxidase 2Nitric OxideAgedAged, 80 and overFemaleHumansMaleMiddle AgedOxidative StressArginineCYBB protein, humanNADPH Oxidase 2Nitric OxideN,N-dimethylarginineAcute ischemic strokeADMALeptomeningeal collateralsNOX2Reperfusion

Identifiers

PMID41436533
PMCPMC12780191

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.