Evidence map›Paper›PMID 41436600›Full record

ArticleCellular & molecular immunology2026

C/EBPβ-induced alternative splicing of RCAN1 generates a potent TCR-T target in mesenchymal glioblastoma.

Zujian Xiong, Qinglin Kong, Bhuvitha Chagantipati, Amelia Stepniak, Ambika P Jaswal, Chaim T Sneiderman, Yuanyuan Han, Sydney A Jackson, Rebecca A Raphael, Wei Zhang and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

Zujian XiongDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0003-2943-1931
Qinglin KongDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Bhuvitha ChagantipatiDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0002-5369-5910
Amelia StepniakDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Ambika P JaswalDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Chaim T SneidermanDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Yuanyuan HanDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Sydney A JacksonDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Rebecca A RaphaelUPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Wei ZhangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Muzi LiThe Second School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, China.
Yapeng ChaoDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Bin QinDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Zeynep DulkadirDepartment of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.
Lance SchwegmanDepartment of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.
Yihao ZhangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chloe KuminkoskiDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Megan A MahlkeUPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Poulomi NathUPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Baoli HuDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-2737-6871
Pascal O ZinnDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Megan ManticaUPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Sameer AgnihotriDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-6584-3795
Yael Nechemia-ArbelyUPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Ian F PollackDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-1765-357X
Lora H RigattiUPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Thomas G ForsthuberDepartment of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.
Xuejun LiDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Itay RaphaelDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. Itay.Raphael@mail.huji.ac.il.ORCID http://orcid.org/0000-0002-7369-2752
Gary KohanbashDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. gary.kohanbash2@chp.edu.ORCID http://orcid.org/0000-0002-3953-8022

Funding

VECTOR CORE FACILITYP30CA047904 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1988 to 2025
$32.4M
NCI NIH HHS P30 CA047904United States Department of Defense | Office of the Secretary of Defense (OSD) HT9425-24-1-0623
6 · The paper itself

Abstract

Glioblastoma (GBM) is an aggressive brain tumor with limited treatment options and a dismal prognosis. While immunotherapy has shown promise in treating some solid tumors, the treatment of GBM has been mostly unsuccessful because of a lack of targetable tumor antigens and high tumor heterogeneity. Here, we report RCAN1-4 as a novel tumor antigen derived from alternative splicing induced by the transcription factor C/EBPβ. Both C/EBPβ and RCAN1-4 are highly expressed in GBM and glioma stem cells as mesenchymal subtype hallmarks. We report an immunogenic HLA-A24-specific splicing junction epitope within exon 4 and exon 5 that is unique to RCAN1-4. This epitope was validated for its ability to stimulate T cell responses in HLA-A24

Indexed as

Alternative SplicingBrain NeoplasmsCCAAT-Enhancer-Binding Protein-betaGlioblastomaIntracellular Signaling Peptides and ProteinsReceptors, Antigen, T-CellT-LymphocytesAnimalsAntigens, NeoplasmCell Line, TumorHumansMiceAntigens, NeoplasmCCAAT-Enhancer-Binding Protein-betaIntracellular Signaling Peptides and ProteinsReceptors, Antigen, T-CellAlternative splicingAntigen detectionGBMRCAN1TCR-T

Identifiers

PMID41436600
PMCPMC12753782

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.