ReviewUrologie (Heidelberg, Germany)2026
[Drug interactions in uro-oncology].
Review in Urologie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
backgroundModern treatments in uro-oncology are increasingly based on therapeutics with complex metabolism in the human body and are associated with an increased risk of drug interactions.
objectiveThis article provides an overview of the most prevalent mechanisms of drug interaction within uro-oncologic therapies and points towards their potential management.
methodsAnti-cancer agents were compiled from the German National Guidelines for the respective indications. Metabolization pathways and potential for drug interactions for those therapeutic drugs as well as the most prevalent drugs for the treatment of concomitant conditions were collected through review of the German prescribing Information (Fachinfo®, www.fachinfo.de ) and an American-based drug information database (uptodate®, www.uptodate.com ). For the most frequent interactions, a pharmaceutical and medical assessment was performed.
resultsFor most anti-cancer agents, metabolization via CYP isoenzymes and transport proteins like p‑glycoprotein play a significant role.
conclusionEspecially interactions with CYP enzymes like 3A4 are critical as they have potential repercussions on efficacy, safety, and quality of life. Clinical management of concomitant oral anticoagulation or in therapeutically limiting comorbidities (like immunosuppression) are particularly challenging.
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41436653What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.