ArticleScientific reports2025
NEDD4 suppresses ferroptosis in lung ischemia-reperfusion injury by ubiquitinating and degrading SLC1A5.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Evolution in lung IRI cell death research: a 20-year global bibliometric study (2005-2024).Annals of medicine and surgery (2012) · 2026Review
- Necroptosis in alveolar epithelium orchestrates lung ischemia-reperfusion injury: a multi-omics study.Respiratory research · 2026Article
- The role of HECT-type E3 ubiquitin ligases in inflammation.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Lung ischemia-reperfusion injury (LIRI) is a critical complication in thoracic surgery and transplantation, driven partly by ferroptosis. While the E3 ubiquitin ligase neural precursor cell expressed, developmentally down-regulated 4 (NEDD4) mitigates ferroptosis in other organs, its role in pulmonary ferroptosis remains unexplored. We screened screened NEDD4 interactors in pulmonary epithelial cells through TurboID proximity proteomics. And functional validation was utilized, including murine LIRI models (WT/NEDD4
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