Evidence map›Paper›PMID 41436812›Full record

ArticleScientific reports2025

In vivo imaging analyses to explore the integration of multimodal aversive sensory information in the central amygdala.

Xinliang Zhou, Yuta Sakuragi, Chiaki Katagiri, Hiroshi Nomura, Masabumi Minami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinliang ZhouDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Yuta SakuragiDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Chiaki KatagiriDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Hiroshi NomuraEndowed Department of Cognitive Function and Pathology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Masabumi MinamiDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan. mminami@pharm.hokudai.ac.jp.

Funding

Japan Agency for Medical Research and Development 24gm1510008Japan Science and Technology Agency JPMJSP2119
6 · The paper itself

Abstract

The negative emotions elicited by diverse aversive sensory stimuli induce avoidance behaviors and adaptive autonomic/hormonal responses, which are crucial for biological defense and homeostasis. The central amygdala (CeA), which receives a range of sensory information, plays important roles in stress and emotional responses. However, it remains unclear whether diverse sensory information from different sensory systems, such as the pain, olfactory, and gustatory systems, is received by the same group of CeA neurons and then integrated to generate negative emotions, or whether different neural pathways are used to generate negative emotions without converging on a specific group of CeA neurons. To clarify this issue, we conducted in vivo Ca

Indexed as

AmygdalaCentral Amygdaloid NucleusAnimalsAvoidance LearningCalciumEmotionsMaleMiceNeuronsPainCalciumAversive sensory stimuliCa2+ imagingCentral amygdalaNegative emotion

Identifiers

PMID41436812
PMCPMC12727694

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.