ArticleBMC pediatrics2025
Systemic immune inflammatory index (SII) as a predictive marker for the failure of air enema treatment in children with Ileocolic intussusception: a case-control study.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Biomarker-Based Prediction of Treatment Outcomes in Pediatric Intussusception: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Predictive and Prognostic Biomarkers in Pediatric Intussusception-A Systematic Review.Journal of clinical medicine · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe systemic immune inflammatory index (SII) is an emerging inflammatory marker and the effectiveness of air enema treatment may correlate with the degree of intestinal inflammation caused by ileocolic intussusception (ICI). Our goal was to identify the SII as a predictor of air enema failure, so that pediatric surgeons can perform surgical intervention in children with ICI as soon as possible, to minimize complications.
methodsThis single-center, retrospective, case-control study was conducted on children with ileocolic intussusception between 2017 and 2024. The admission demographic, clinical, and laboratory data were analyzed. The specificity and sensitivity of various parameters as predictors of the failure of air enema treatment were established using receiver operating characteristic (ROC) curves.
resultsA total of 574 patients were included in the study (469 in the air enema success group and 105 in the air enema failure group). There was an independent positive correlation between SII and the risk of air enema treatment failure in ICI. Additionally, a nonlinear dose–response relationship was observed between SII and air enema treatment failure in ICI within the RCS. Threshold analysis revealed that on the right of this inflection point 332.3, there was a significant 25% increase in the prevalence of air enema treatment failure risk of ICI per 100-unit increase in the SII (OR: 1.25, 95%CI: 1.17–1.32). In the ROC curve analysis, SII demonstrated the highest area under the curve (AUC) of 0.8665 (95%CI: 0.8313–0.9018) compared to other inflammation indices. The critical point for SII was estimated to be 721.5 (sensitivity, 86.67%; specificity, 71.00%).
conclusionsThe SII, a novel, cost-effective, and objective inflammatory marker, can be utilized to predict the risk of air enema treatment failure in children with ileocolic intussusception.
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