Evidence map›Paper›PMID 41437102›Full record

ReviewJournal of ovarian research2025

Mesenchymal stem cells and their promise in reversing ovarian aging.

Dongmei Yao, Hong Chen, Jianlong Yuan, Peixin Xu, Xin Guo, Jing Gao, Xin Li, Tong Wang, Yurong Wang, Bingchun Liu and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dongmei Yao *Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Hong Chen *Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Jianlong YuanDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Peixin XuDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Xin GuoDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Jing GaoDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Xin LiDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Tong WangDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Yurong WangDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Bingchun LiuCentral Laboratory of Organ Transplantation / Stem Cell Laboratory / Inner Mongolia Autonomous Region Engineering Laboratory for Genetic Test and Research of Tumor Cells, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China. liubc@immu.edu.cn.
Yang LiuDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China. liuyang@immu.edu.cn.

Funding

2024 Joint Fund for Research in Public Hospitals Science and Technology Projects 2024GLLH0298Affiliated Hospital of Inner Mongolia Medical University National Nature Cultivation Programme 2023NYFYPY006Central Guided Local Science and Technology Development Funds Project 2023ZY0004Inner Mongolia Autonomous Region Provincial Health Commission, Science and Technology Program for Building High-level Clinical Specialties in Public Hospitals in the Capital Region 2024SGGZ071Inner Mongolia Science and Technology Project 2025YFSH0089Key Research and Development and Achievement Transformation Program of Inner Mongolia Autonomous Region 2025YFSH0093National Natural Science Foundation of China 31960154Natural Science Foundation of Inner Mongolia 2023QN03047Science and Technology Project of the Scientific Research Joint Fund for Public Hospitals in Inner Mongolia Autonomous Region 2024GLLH0321Scientific Research Project of Inner Mongolia Autonomous Region Colleges and Universities NJZZ23017Youth Innovation Talents Training Program of the Inner Mongolia Autonomous Region"Prairie excellence"Project Q2022085
6 · The paper itself

Abstract

Ovarian aging is accompanied by a decline in the quantity and quality of follicles, leading to reduced fertility. Ovarian aging encompasses natural aging due to DNA damage, telomere attrition, and mitochondrial dysfunction, as well as a pathological functional failure caused by environmental toxins, known as a premature ovarian failure. Cell therapy is currently a focal point of research, with mesenchymal stem cells (MSCs) being particularly notable due to their wide availability, ease of expansion, strong self-renewal capabilities, multipotent differentiation, and paracrine functions. MSCs have shown great potential in the field of cell therapy, including delaying ovarian aging. MSCs can delay ovarian aging through various mechanisms: antioxidation, differentiation and regeneration, promotion of cell proliferation, inhibition of cell apoptosis, and anti-inflammatory responses. Currently, MSCs transplantation has achieved significant results in animal models, improving ovarian function and enhancing fertility. However, clinical applications still face numerous challenges, such as determining the optimal cell source, transplantation route, dosage, and long-term safety, which require further research. In this review, we will elaborate on the mechanisms of ovarian aging, the modes of action of MSCs, and the mechanisms by which MSCs delay ovarian aging, aiming to provide a theoretical basis for the clinical application of MSCs and to bring breakthroughs in the treatment of diseases such as premature ovarian failure.

Indexed as

AgingMesenchymal Stem CellsMesenchymal Stem Cell TransplantationOvaryAnimalsFemaleHumansPrimary Ovarian InsufficiencyCell therapyDelay agingMesenchymal stem cellsOvarianSenescence

Identifiers

PMID41437102
PMCPMC12728997

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.