ArticleBMC plant biology2025
Metabolic profiling of red-fleshed apple and functional characterization of MdERF072 in anthocyanin biosynthesis.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tissue-Resolved Metabolomic Profiling of TenFoods (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundRed-fleshed apples, with their flavonoid-rich edible flesh, offer superior nutritional advantages over traditional varieties, where these antioxidants are concentrated primarily in the less-consumed peel. The distinct metabolic profile of red-fleshed apples, particularly their compositional uniqueness and deposition characteristics, therefore requires systematic deconstruction through comparative metabolomics.
resultsIn this work, comparative metabolomics of three apple cultivars with distinct flesh coloration revealed a substantial upregulation of specialized flavonoids in the red-fleshed variety. Notably, we identified an accumulation of polymethoxyflavones (PMFs) with antitumor activity and found cyanidin-3-O-glucoside to be the predominant anthocyanin responsible for red pigmentation in red-fleshed apple. Conversely, the accumulation of flavan-3-ols and proanthocyanidins (PAs) was decreased in red-fleshed apple. Volatile metabolome analysis interestingly demonstrated that the majority of volatile organic compounds (VOCs), such as esters, terpenoids, and alcohols, were significantly more abundant in the red-fleshed apple. Transcriptomic profiling revealed the upregulation of key flavonoid pathway genes, including early synthase genes (PAL, C4H, 4CL, CHS) and anthocyanin-specific genes (UFGT, GST), in red-fleshed apple, consistent with the observed accumulation of PMFs and anthocyanins in the flesh. Conversely, the downregulation of LAR and ANR accounts for the reduced biosynthesis of flavan-3-ols and PAs in the red-fleshed apple. Systematic TF screening, expression analyses and transient verification assays revealed that MdERF072 acts as an important transcriptional activator of anthocyanin biosynthesis and potentially upregulates the expression of structural genes in the anthocyanin pathway.
conclusionsOverall, this work reveals the metabolic and transcriptional basis of flavonoid enrichment in red-fleshed apple and provides a foundation for breeding nutritionally improved cultivars.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.