ReviewJournal of translational medicine2025
Research progress on the mechanisms of cGAS-STING signaling in immune cell infiltration associated with vascular remodeling.
Review in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Identification of neutrophil extracellular traps-related genes as feature genes and potential therapeutic targets in pulmonary hypertension.Journal of thoracic disease · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVascular remodeling is a hallmark of various cardiovascular diseases and is increasingly recognized as an immune-mediated process. Recent evidence has identified the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway as a critical mediator linking cytosolic DNA sensing to innate immune activation. Beyond its classical role in host defense against pathogens, the cGAS-STING pathway plays a pivotal role in regulating the recruitment, activation, and functional polarization of diverse immune cell populations, including macrophages, neutrophils, T cells, B cells, dendritic cells, and eosinophils, thereby contributing to vascular inflammation and pathological remodeling. MAIN TEXT: This review summarizes recent advances in understanding how cGAS-STING signaling governs immune cell infiltration and intercellular communication that underlie vascular remodeling. We also explore the direct effects of cGAS-STING activation on vascular endothelial and smooth muscle cells, and its crosstalk with other key signaling pathways such as Toll-like receptors (TLRs), Hippo-YAP, and bone morphogenetic proteins (BMPs). In addition, we discuss current and emerging therapeutic strategies targeting this pathway, including small-molecule inhibitors and combination therapies utilizing nano-delivery systems.
conclusionsBy highlighting the role of immune cell infiltration as a novel therapeutic axis, this review provides new perspectives for the modulation of vascular remodeling and the treatment of cardiovascular diseases. These insights may inform future research on pathway-specific interventions and the development of personalized therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.