Evidence map›Paper›PMID 41437332›Full record

ArticleBMC geriatrics2025

A study on the correlation between novel metabolic and inflammatory-derived indicators (TyG, THR, NHR, UHR) and overweight older adult patients with T2DM.

Xiaoxiang Zhang, Jiaojiao Li, Manjie Wang, Tiantian Tang, Xinyu Sun, Cancan Hui, Yuwei Cheng, Xiaoming Kong, Yan Sun

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In one paragraph

Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiaoxiang ZhangDepartment of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei, China.
Jiaojiao LiDepartment of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei, China.
Manjie WangDepartment of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei, China.
Tiantian TangDepartment of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei, China.
Xinyu SunDepartment of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei, China.
Cancan HuiDepartment of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei, China.
Yuwei ChengDepartment of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei, China.
Xiaoming KongDepartment of Geriatric Psychiatry, Hefei Fourth People's Hospital, Anhui Province, Hefei, China. kxm186@163.com.
Yan SunDepartment of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei, China. syan956@163.com.

Funding

Anhui Medical University Research Fund Project 2021xkj144Key Projects of Natural Science Research Program of Higher Education Institutions in Anhui Province 2023AH053309National Natural Science Foundation of China 82072134
6 · The paper itself

Abstract

objectiveTo evaluate the correlation between novel metabolic and inflammatory-derived Indicators (TyG, THR, NHR, UHR) for overweight in older adult type 2 diabetes mellitus (T2DM) patients.

methodsThis study enrolled 183 hospitalized older adult T2DM patients (aged ≥ 60 years) from 2023 to 2024. Participants were stratified into overweight (24 ≤ BMI < 28, n = 85) and normal-weight groups (18.5 ≤ BMI < 24, n = 98). Clinical parameters including TyG, THR, NHR, and UHR were calculated. Statistical analyses involved t-tests, logistic regression, Spearman correlation, and ROC curves.

resultsKey metabolic/inflammatory derived indices (TyG, THR, NHR, UHR) were significantly elevated in overweight group versus normal group (all P < 0.05). BMI showed positive correlations with TyG, THR, NHR, and UHR (all P < 0.05). Logistic regression confirmed the TyG, THR, NHR and UHR index are significantly associated with the development of overweight in T2DM patients (all P < 0.05). After adjusting for confounders, TyG demonstrated the highest predictive accuracy for overweight status (AUC = 0.732), followed by THR, NHR and UHR.

conclusionTyG, THR, NHR and UHR are significantly associated with overweight in older adult T2DM, potentially serving as simple screening tools for early metabolic risk stratification and weight management.

Indexed as

Diabetes Mellitus, Type 2InflammationOverweightAgedBiomarkersBody Mass IndexFemaleHumansMaleMiddle AgedBiomarkersChronic inflammationGeriatricsOlder adult patientsOverweightTriglyceride-glucose indexType 2 diabetes mellitus

Identifiers

PMID41437332
PMCPMC12836823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.