ArticleJournal of translational medicine2025
Distinct gut microbiome profiles in Korean systemic lupus erythematosus patients.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
backgroundSystemic lupus erythematosus (SLE) is an autoimmune disease associated with systemic inflammation and multi-organ involvement. Emerging evidence suggests that gut microbiota dysbiosis may contribute to its immunopathogenesis.
objectiveThis study aimed to characterize gut microbial composition and diversity in Korean SLE patients and evaluate associations with clinical features.
methodsFecal samples from 157 SLE patients and 50 healthy controls (HC) were analyzed using 16S rRNA gene sequencing. Alpha and beta diversity metrics were assessed, and taxonomic differences were analyzed. Subgroup comparisons were conducted based on lupus nephritis (LN) status and disease activity. Functional predictions were inferred using PICRUSt2.
resultsSLE patients exhibited significantly reduced microbial richness (Chao1, ACE, Fisher indices), while evenness (Shannon, Simpson) was preserved. Beta diversity analysis revealed distinct clustering between SLE and HC groups. SLE was characterized by enrichment of Bacteroides, Streptococcus, and Veillonella, and depletion of Collinsella, Ruminococcus, and Bifidobacterium. LEfSe identified several discriminatory taxa. However, no significant microbial differences were observed between LN-positive and LN-negative groups or between high and low disease activity groups. Functional prediction revealed minimal differences in microbial pathways between groups.
conclusionThese findings highlight distinct gut microbial alterations in Korean SLE patients and support the potential utility of microbiome profiles as diagnostic biomarkers or therapeutics.
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