Evidence map›Paper›PMID 41437806›Full record

ReviewAllergy2026

Sequence of Immunological Events During IgE-Mediated Allergic Reactions to Food.

N A Nagy, D Schnoegl, V Houghton, L O'Mahony, A F Santos, E F Knol, A Kuehn, T Eiwegger

Abstract readReview
In one paragraph

Review in Allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

N A NagyDepartment of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.ORCID https://orcid.org/0009-0006-8719-3336
D SchnoeglKarl Landsteiner University of Health Sciences, Krems, Austria.ORCID https://orcid.org/0009-0004-9633-8299
V HoughtonPeter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0001-6307-6529
L O'MahonyDepartment of Medicine and Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.ORCID https://orcid.org/0000-0003-4705-3583
A F SantosPeter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0002-7805-1436
E F KnolCenter of Translational Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0001-7368-9820
A KuehnDepartment of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.ORCID https://orcid.org/0000-0003-0474-2135
T EiweggerKarl Landsteiner University of Health Sciences, Krems, Austria.ORCID https://orcid.org/0000-0002-2914-7829

Funding

Austrian Science FundFonds National de la Recherche Luxembourg
6 · The paper itself

Abstract

Food allergies (FA) represent a significant global health burden. Upon allergen re-exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds. This review focuses on the sequence of immediate immunological and clinical events that occur during allergen exposure in individuals with FA. It highlights both clinical and immunological baseline risk factors and discusses recent advances in understanding the acute allergic response. We explore the implications of immune mechanistic knowledge for predicting clinical reactivity and therapy of FA. The current diagnostic gold standard, the oral food challenge (OFC), may help identify early biomarkers for patient stratification and provide insights into the immune dynamics underlying acute allergic reactions in vivo.

Indexed as

Food HypersensitivityImmunoglobulin EAllergensAnimalsHumansAllergensImmunoglobulin Ebasophilsfood allergygastrointestinal tissueIgEimmune mechanismmast cellspeanut allergyT2 responses

Identifiers

PMID41437806
PMCPMC13466000

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.