Evidence map›Paper›PMID 41437862›Full record

ReviewIntegrative zoology2026

Zoonotic Parasite Nanovaccines: Progress, Challenges, and Future Perspectives.

Qiangqiang Wang, Bin Hu, Yuanfeng Wang, Xiaoxuan Feng, Naiwen Zhang, Pengfei Zhao, Shouping Zhang, Ruibiao Wang, Qiuxia Wang, Yanhui Han and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Integrative zoology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qiangqiang WangMinistry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang, Henan, P. R. China.
Bin HuMinistry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang, Henan, P. R. China.
Yuanfeng WangXinxiang Key Laboratory of Pathogenic Biology, Department of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, P. R. China.
Xiaoxuan FengMinistry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang, Henan, P. R. China.
Naiwen ZhangMinistry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang, Henan, P. R. China.
Pengfei ZhaoMinistry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang, Henan, P. R. China.
Shouping ZhangMinistry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang, Henan, P. R. China.
Ruibiao WangMinistry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang, Henan, P. R. China.
Qiuxia WangMinistry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang, Henan, P. R. China.
Yanhui HanMinistry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang, Henan, P. R. China.
Muhammad Tahir AleemDepartment of Pharmacology, Shantou University Medical College, Shantou, China.
Shuai WangXinxiang Key Laboratory of Pathogenic Biology, Department of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, P. R. China.
Hongxuan HeMinistry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang, Henan, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parasitic infections remain major global health challenges, particularly in low- and middle-income countries. Although traditional vaccines have made significant progress against parasites, limited success has been obtained due to the parasites' complex life cycles and immune evasion. Nanoparticle-based vaccines, including mRNA-lipid particles, polymeric particles, and virus-like particles (VLPs), offer a promising alternative, showing improved immunogenicity in trials. In this study, the recent advancements in nanoparticle-based vaccines for parasitic infections and the roles of various types of nanoparticles are summarized in detail. Furthermore, the existing challenges regarding the parasite nanovaccines, such as clinical, ethical, and regulatory hurdles, are analyzed, and the constructive perspectives for future studies are provided simultaneously. This review will contribute to the understanding of functions and the current status of parasite nanovaccines, prompting the development of next-generation parasite nanovaccines.

Indexed as

NanovaccinesParasitic DiseasesZoonosesAnimalsHumansNanoparticlesNanovaccinesmRNA–lipid particlesnanoparticle‐based vaccinesparasitic infectionspolymeric particlesvirus‐like particles

Identifiers

PMID41437862
PMCPMC13574185

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.